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Study · Animal study (in vivo) · rat · 2006

5 results

The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.

Rössler AS, Pfaus JG, Kia HK, Bernabé J, Alexandre L, Giuliano F

Pharmacology, biochemistry, and behavior20 Nov 2006Cited by 32 (Europe PMC)

PMID17113634 (opens in a new tab)DOI10.1016/j.pbb.2006.09.023 (opens in a new tab)PepBankPUB-17113634
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats primed with estradiol benzoate and progesterone, both MT-II doses significantly increased hops and darts.

    In plain wordsIn female rats primed with hormones, Melanotan II increased solicitation behaviors toward males.

    Peptide
    Melanotan II
    Outcome
    IncreaseHops and darts (EB+P primed)
    Study

    ratn = 7

    Ovariectomized Long-Evans female rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 and 3 mg/kg · intravenous · Single injection 10 min before each 30-min paced mating testAs given in this study (rat).

    Source sentences

    Summary
    In females primed with EB+P both doses of MT-II increased the number of hops and darts
    2 context sentences
    Summary · context
    One group of ovariectomized Long-Evans rats (n=7) was primed subcutaneously with estradiol benzoate (EB) and progesterone (P) (10 microg and 500 microg respectively) and another group (n=7) with EB (10 microg) and oil (EB alone).
    Summary · context
    MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats primed with estradiol benzoate and progesterone, both MT-II doses significantly increased ear wiggling.

    In plain wordsIn female rats primed with hormones, Melanotan II increased ear wiggling, a sexual-interest behavior.

    Peptide
    Melanotan II
    Outcome
    IncreaseEar wiggling (EB+P primed)
    Study

    ratn = 7

    Ovariectomized Long-Evans female rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 and 3 mg/kg · intravenous · Single injection 10 min before each 30-min paced mating testAs given in this study (rat).

    Source sentences

    Summary
    ear wiggling significantly
    2 context sentences
    Summary · context
    One group of ovariectomized Long-Evans rats (n=7) was primed subcutaneously with estradiol benzoate (EB) and progesterone (P) (10 microg and 500 microg respectively) and another group (n=7) with EB (10 microg) and oil (EB alone).
    Summary · context
    MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats primed with estradiol benzoate and progesterone, MT-II did not alter pacing.

    In plain wordsIn female rats primed with hormones, Melanotan II did not change pacing behavior.

    Peptide
    Melanotan II
    Outcome
    No significant changePacing (EB+P primed)
    Study

    ratn = 7

    Ovariectomized Long-Evans female rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 and 3 mg/kg · intravenous · Single injection 10 min before each 30-min paced mating testAs given in this study (rat).

    Source sentences

    Summary
    but did not alter pacing or lordosis.
    2 context sentences
    Summary · context
    One group of ovariectomized Long-Evans rats (n=7) was primed subcutaneously with estradiol benzoate (EB) and progesterone (P) (10 microg and 500 microg respectively) and another group (n=7) with EB (10 microg) and oil (EB alone).
    Summary · context
    MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats primed with estradiol benzoate and progesterone, MT-II did not alter lordosis.

    In plain wordsIn female rats primed with hormones, Melanotan II did not change the mating receptivity posture.

    Peptide
    Melanotan II
    Outcome
    No significant changeLordosis (EB+P primed)
    Study

    ratn = 7

    Ovariectomized Long-Evans female rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 and 3 mg/kg · intravenous · Single injection 10 min before each 30-min paced mating testAs given in this study (rat).

    Source sentences

    Summary
    but did not alter pacing or lordosis.
    2 context sentences
    Summary · context
    One group of ovariectomized Long-Evans rats (n=7) was primed subcutaneously with estradiol benzoate (EB) and progesterone (P) (10 microg and 500 microg respectively) and another group (n=7) with EB (10 microg) and oil (EB alone).
    Summary · context
    MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats primed with estradiol benzoate alone, MT-II had no effect on any of the sexual behavior parameters measured.

    In plain wordsIn female rats primed with only one hormone, Melanotan II did not change any measured sexual behavior.

    Peptide
    Melanotan II
    Outcome
    No significant changeAll sexual behavior parameters (EB alone primed)
    Study

    ratn = 7

    Ovariectomized Long-Evans female rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 and 3 mg/kg · intravenous · Single injection 10 min before each 30-min paced mating testAs given in this study (rat).

    Source sentences

    Summary
    With EB alone, no effect of MT-II was observed on any of the parameters measured.
    2 context sentences
    Summary · context
    One group of ovariectomized Long-Evans rats (n=7) was primed subcutaneously with estradiol benzoate (EB) and progesterone (P) (10 microg and 500 microg respectively) and another group (n=7) with EB (10 microg) and oil (EB alone).
    Summary · context
    MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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