Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine.

Larsen MH, Rosenbrock H, Sams-Dodd F, Mikkelsen JD

European journal of pharmacology19 Oct 2006Cited by 36 (Europe PMC)

PMID17112503DOI10.1016/j.ejphar.2006.10.029PepBankPUB-17112503

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, chronic tesofensine increased hippocampal CA3 BDNF mRNA by 35%.
In plain wordsIn rats, chronic tesofensine increased BDNF gene expression in the hippocampal CA3 region.
Peptide
Tesofensine
Outcome
IncreaseCA3 BDNF mRNA after chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Measurements
BDNF mRNA increase
35%
CA3, chronic treatment
Source sentences
Summary
We find that chronic, but not sub-chronic treatment with Tesofensine increases BDNF mRNA in the CA3 region of the hippocampus (35%), and Arc mRNA in the CA1 of the hippocampus (65%).
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250301
02AnimalAnimal study (in vivo)Mechanism
In rats, sub-chronic tesofensine did not increase hippocampal CA3 BDNF mRNA.
In plain wordsIn rats, sub-chronic tesofensine did not increase BDNF gene expression in the hippocampal CA3 region.
Peptide
Tesofensine
Outcome
No significant changeCA3 BDNF mRNA after sub-chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 5 daysAs given in this study (rat).
Source sentences
Summary
We find that chronic, but not sub-chronic treatment with Tesofensine increases BDNF mRNA in the CA3 region of the hippocampus (35%), and Arc mRNA in the CA1 of the hippocampus (65%).
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250302
03AnimalAnimal study (in vivo)Mechanism
In rats, chronic tesofensine increased hippocampal CA1 Arc mRNA by 65%.
In plain wordsIn rats, chronic tesofensine increased Arc gene expression in the hippocampal CA1 region.
Peptide
Tesofensine
Outcome
IncreaseCA1 Arc mRNA after chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Measurements
Arc mRNA increase
65%
CA1, chronic treatment
Source sentences
Summary
We find that chronic, but not sub-chronic treatment with Tesofensine increases BDNF mRNA in the CA3 region of the hippocampus (35%), and Arc mRNA in the CA1 of the hippocampus (65%).
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250303
04AnimalAnimal study (in vivo)Mechanism
In rats, sub-chronic tesofensine did not increase hippocampal CA1 Arc mRNA.
In plain wordsIn rats, sub-chronic tesofensine did not increase Arc gene expression in the hippocampal CA1 region.
Peptide
Tesofensine
Outcome
No significant changeCA1 Arc mRNA after sub-chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 5 daysAs given in this study (rat).
Source sentences
Summary
We find that chronic, but not sub-chronic treatment with Tesofensine increases BDNF mRNA in the CA3 region of the hippocampus (35%), and Arc mRNA in the CA1 of the hippocampus (65%).
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250304
05AnimalAnimal study (in vivo)Mechanism
In rats, chronic tesofensine increased hippocampal Ki-67-positive cells.
In plain wordsIn rats, chronic tesofensine increased hippocampal cells positive for Ki-67.
Peptide
Tesofensine
Outcome
IncreaseKi-67-positive cells after chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, the number of Ki-67- and neuroD-positive cells increased after chronic, but not sub-chronic treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250305
06AnimalAnimal study (in vivo)Mechanism
In rats, sub-chronic tesofensine did not increase hippocampal Ki-67-positive cells.
In plain wordsIn rats, sub-chronic tesofensine did not increase hippocampal cells positive for Ki-67.
Peptide
Tesofensine
Outcome
No significant changeKi-67-positive cells after sub-chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 5 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, the number of Ki-67- and neuroD-positive cells increased after chronic, but not sub-chronic treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250306
07AnimalAnimal study (in vivo)Mechanism
In rats, chronic tesofensine increased hippocampal neuroD-positive cells.
In plain wordsIn rats, chronic tesofensine increased hippocampal cells positive for neuroD.
Peptide
Tesofensine
Outcome
IncreaseNeuroD-positive cells after chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, the number of Ki-67- and neuroD-positive cells increased after chronic, but not sub-chronic treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250307
08AnimalAnimal study (in vivo)Mechanism
In rats, sub-chronic tesofensine did not increase hippocampal neuroD-positive cells.
In plain wordsIn rats, sub-chronic tesofensine did not increase hippocampal cells positive for neuroD.
Peptide
Tesofensine
Outcome
No significant changeNeuroD-positive cells after sub-chronic treatment
Study
ratn: not reported in source
Rat hippocampus
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 5 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, the number of Ki-67- and neuroD-positive cells increased after chronic, but not sub-chronic treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
This study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of Tesofensine on the expression of brain derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) in the rat hippocampus.
Summary · context
Furthermore, hippocampi from the same animals were used to investigate the effect on cell proliferation by means of Ki-67- and NeuroD-immunoreactivity.
Report a problemFND-1711250308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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