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Study · Randomized controlled trial · n = 22 · 2007

7 results

Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans.

Kvorning T, Andersen M, Brixen K, Schjerling P, Suetta C, Madsen K

The Journal of physiology9 Nov 2006Cited by 53 (Europe PMC)

PMID17095559 (opens in a new tab)DOI10.1113/jphysiol.2006.122671 (opens in a new tab)PepBankPUB-17095559
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In young men, goserelin reduced resting testosterone from 22.6 +/- 1.6 to 2.0 +/- 0.1 nmol l(-1), while placebo levels remained unchanged.

    In plain wordsIn young men, goserelin reduced resting testosterone compared with unchanged levels with placebo.

    Peptide
    Goserelin
    Outcome
    DecreaseResting testosterone
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Measurements

    Resting serum testosterone
    22.6 nmol/l
    goserelin group, before
    Resting serum testosterone
    2 nmol/l
    goserelin group, week 4

    Source sentences

    Summary
    Resting serum testosterone decreased significantly (P < 0.01) in the goserelin group from 22.6 +/- 1.6 (mean +/- s.e.m.) to 2.0 +/- 0.1 nmol l(-1) (week 4), whereas it remained unchanged in the placebo group.
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In young men, acute testosterone response decreased with goserelin but increased with placebo during the final strength training session.

    In plain wordsIn young men, goserelin reduced the acute testosterone response compared with an increase with placebo.

    Peptide
    Goserelin
    Outcome
    DecreaseAcute testosterone response to training
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    An acute increase of serum testosterone was observed during the final ST session in the placebo group (P < 0.05), whereas a decreased response was observed in the goserelin group (P < 0.05).
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In young men, IGF-IE(bc) mRNA increased with training, with no difference between goserelin and placebo.

    In plain wordsIn young men, IGF-IE(bc) expression increased with training but did not differ between goserelin and placebo.

    Peptide
    Goserelin
    Outcome
    No significant changeIGF-IE(bc) mRNA expression
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0.01); however, no differences were observed between the groups.
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In young men, myogenin mRNA increased with training, with no difference between goserelin and placebo.

    In plain wordsIn young men, myogenin expression increased with training but did not differ between goserelin and placebo.

    Peptide
    Goserelin
    Outcome
    No significant changeMyogenin mRNA expression
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0.01); however, no differences were observed between the groups.
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In young men, myostatin mRNA decreased with training, with no difference between goserelin and placebo.

    In plain wordsIn young men, myostatin expression decreased with training but did not differ between goserelin and placebo.

    Peptide
    Goserelin
    Outcome
    No significant changeMyostatin mRNA expression
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0.01); however, no differences were observed between the groups.
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In young men, muscle strength tended to increase less with goserelin than placebo (P = 0.05).

    In plain wordsIn young men, muscle strength tended to increase less with goserelin than placebo.

    Peptide
    Goserelin
    Outcome
    DecreaseMuscle strength
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Muscle strength and muscle mass showed a tendency to increase more in the placebo group than in the goserelin group (P = 0.05).
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In young men, muscle mass tended to increase less with goserelin than placebo (P = 0.05).

    In plain wordsIn young men, muscle mass tended to increase less with goserelin than placebo.

    Peptide
    Goserelin
    Outcome
    DecreaseMuscle mass
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Body composition · Musculoskeletal
    Studied dose
    3.6 mg every 4 weeks · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Muscle strength and muscle mass showed a tendency to increase more in the placebo group than in the goserelin group (P = 0.05).
    2 context sentences
    Summary · context
    Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks.
    Summary · context
    The ST period of 8 weeks started at week 4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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