Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells.

Selkirk JV, Nottebaum LM, Lee J, Yang W, Foster AC, Lechner SM

Neuropharmacology7 Nov 2006Cited by 25 (Europe PMC)

PMID17095023DOI10.1016/j.neuropharm.2006.08.015PepBankPUB-17095023

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cultured rat astrocytes, MTII produced a cAMP response of 55% of the maximal response elicited by alpha-MSH.
In plain wordsIn cells, MTII gave a cAMP response that was 55% of the maximum response to alpha-MSH in rat astrocytes.
Peptide
Melanotan II
Outcome
Not applicablecAMP maximal response in astrocytes
Study
ratn: not reported in source
cultured rat cortical astrocytes (native MC4R)
Comparator
alpha-MSH maximal response
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Measurements
Maximal cAMP response relative to alpha-MSH
55%
rat astrocytes
Source sentences
Summary
Likewise, the peptides MTII and ACTH display 55 and 72% of the maximal response elicited by alpha-MSH in these cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Using cAMP accumulation as a functional readout, we pharmacologically characterized the response of native melanocortin receptors in cultured rat astrocytes, and found this response to be mediated by the melanocortin 4 receptor (MC4R)
Report a problemFND-1709502301

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

02LabNot a test of Melanotan II aloneIn vitro (cells)Activity measurement
In HEK cells expressing rat MC4R, small-molecule and peptide melanocortin agonists, including MTII, all elicited full agonist responses with intrinsic activity similar to alpha-MSH.
In plain wordsIn lab cells, a group of melanocortin agonists, including MTII, all gave full responses similar to alpha-MSH.
Peptide
Melanotan II
Outcome
Not applicablecAMP intrinsic activity in HEK-rMC4R cells
Study
humann: not reported in source
HEK cells expressing rat MC4R (HEK-rMC4R)
Comparator
alpha-MSH
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
In contrast, all of these compounds elicit full agonist responses with similar intrinsic activity to alpha-MSH in HEK-rMC4R cells.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-1709502302

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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