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Study · Animal study (in vivo) · mouse · 2007

5 results

The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model.

Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA

Journal of psychopharmacology (Oxford, England)8 Nov 2006Cited by 33 (Europe PMC)

PMID17092975 (opens in a new tab)DOI10.1177/0269881106071335 (opens in a new tab)PepBankPUB-17092975
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In bulbectomized mice, Noopept restored spatial memory.

    In plain wordsIn mice with removed olfactory bulbs, Noopept restored spatial memory.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseSpatial memory
    Study

    mousen: not reported in source

    Olfactory-bulbectomized NMRI mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.01 mg/kg · 21 days and a further 5 days trainingAs given in this study (mouse).

    Source sentences

    Summary
    Noopept (administered at a dose of 0.01 mg/kg for a period of 21 days and during a further 5 days training) restored spatial memory and increased serum antibody levels to oligomers of Abeta((25-35)) peptide but not to equine lysozyme amyloid or S100b protein in bulbectomized animals.
    1 context sentence
    Summary · context
    The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In bulbectomized mice, Noopept increased serum antibodies to oligomers of Abeta((25-35)) peptide.

    In plain wordsIn mice with removed olfactory bulbs, Noopept increased blood antibodies to amyloid peptide oligomers.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseSerum antibodies to Abeta((25-35)) oligomers
    Study

    mousen: not reported in source

    Olfactory-bulbectomized NMRI mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 mg/kg · 21 days and a further 5 days trainingAs given in this study (mouse).

    Source sentences

    Summary
    Noopept (administered at a dose of 0.01 mg/kg for a period of 21 days and during a further 5 days training) restored spatial memory and increased serum antibody levels to oligomers of Abeta((25-35)) peptide but not to equine lysozyme amyloid or S100b protein in bulbectomized animals.
    1 context sentence
    Summary · context
    The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In bulbectomized mice, Noopept did not increase serum antibodies to equine lysozyme amyloid.

    In plain wordsIn mice with removed olfactory bulbs, Noopept did not increase blood antibodies to equine lysozyme amyloid.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeSerum antibodies to equine lysozyme amyloid
    Study

    mousen: not reported in source

    Olfactory-bulbectomized NMRI mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 mg/kg · 21 days and a further 5 days trainingAs given in this study (mouse).

    Source sentences

    Summary
    Noopept (administered at a dose of 0.01 mg/kg for a period of 21 days and during a further 5 days training) restored spatial memory and increased serum antibody levels to oligomers of Abeta((25-35)) peptide but not to equine lysozyme amyloid or S100b protein in bulbectomized animals.
    1 context sentence
    Summary · context
    The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In bulbectomized mice, Noopept did not increase serum antibodies to S100b protein.

    In plain wordsIn mice with removed olfactory bulbs, Noopept did not increase blood antibodies to S100b protein.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeSerum antibodies to S100b protein
    Study

    mousen: not reported in source

    Olfactory-bulbectomized NMRI mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 mg/kg · 21 days and a further 5 days trainingAs given in this study (mouse).

    Source sentences

    Summary
    Noopept (administered at a dose of 0.01 mg/kg for a period of 21 days and during a further 5 days training) restored spatial memory and increased serum antibody levels to oligomers of Abeta((25-35)) peptide but not to equine lysozyme amyloid or S100b protein in bulbectomized animals.
    1 context sentence
    Summary · context
    The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, the Noopept-associated antibody response to amyloid prefibrillar aggregates was more marked after sham surgery than bulbectomy.

    In plain wordsIn mice, Noopept increased amyloid antibodies more after sham surgery than after olfactory bulb removal.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseAntibody response by surgical condition
    Study

    mousen: not reported in source

    Sham-operated and olfactory-bulbectomized NMRI mice
    Comparator
    Bulbectomized mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 mg/kg · 21 days and a further 5 days trainingAs given in this study (mouse).

    Source sentences

    Summary
    The positive immunotropic effect of noopept to Abeta((25-35)) peptide prefibrillar aggregates was more marked in sham-operated compared to the bulbectomized subjects which were characterized by an overall suppression of immunoreactivity.
    1 context sentence
    Summary · context
    The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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