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Study · Measured the body's own peptide · 2006

3 results

Response of interleukin-1beta in the magnocellular system to salt-loading.

Summy-Long JY, Hu S, Pruss A, Chen X, Phillips TM

Journal of neuroendocrinology1 Dec 2006Cited by 13 (Europe PMC)

PMID17076768 (opens in a new tab)DOI10.1111/j.1365-2826.2006.01490.x (opens in a new tab)PepBankPUB-17076768
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, plasma oxytocin was higher after 8 days of salt-loading with 2% NaCl.

    In plain wordsIn rats, the body's own oxytocin in blood was higher after 8 days of drinking salt water.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after salt-loading
    Study

    ratn: not reported in source

    Salt-loaded rats
    Comparator
    Water-drinking pair-fed controls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    whereas osmolality, OT and cytokine were enhanced after 8 days
    1 context sentence
    Summary · context
    To quantify cytokine depletion from the neural lobe during progressive salt loading and determine whether the changes are reversible and correspond with stores of vasopressin (VP) or oxytocin (OT), rats were given water on day 0 and then 2% NaCl to drink for 2, 5, 8 or 5 days followed by 5 days of water (rehydration).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, oxytocin content of the neural lobe fell progressively with longer salt-loading, starting on day 5, and was not replenished by rehydration.

    In plain wordsIn rats, the body's own oxytocin stored in the pituitary neural lobe fell the longer the animals drank salt water.

    Peptide
    Oxytocin
    Outcome
    DecreaseNeural lobe oxytocin content during salt-loading
    Study

    ratn: not reported in source

    Salt-loaded rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In the neural lobe, all three peptides decreased progressively with increasing duration of salt-loading (IL-1beta, r2 = 0.98; OT, r2 = 0.94; VP, r2 = 0.93), beginning on day 2 (IL-1beta; VP) or 5 (OT), with only VP replenished by rehydration.
    1 context sentence
    Summary · context
    To quantify cytokine depletion from the neural lobe during progressive salt loading and determine whether the changes are reversible and correspond with stores of vasopressin (VP) or oxytocin (OT), rats were given water on day 0 and then 2% NaCl to drink for 2, 5, 8 or 5 days followed by 5 days of water (rehydration).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In salt-loaded rats, neural lobe IL-1beta declined more closely with oxytocin than with vasopressin, which suggests corelease from the neural lobe.

    In plain wordsIn rats, the body's own oxytocin and IL-1beta fell together in the pituitary during salt loading, which hints that they are released together.

    Peptide
    Oxytocin
    Outcome
    Not applicableCo-decline of neural lobe IL-1beta with oxytocin
    Study

    ratn: not reported in source

    Salt-loaded rats
    Outcome group
    Inflammation markers · Endocrine and hormones

    Source sentences

    Summary
    IL-1beta declined more closely (P < 0.0001; ANOVA interaction analysis) with OT (r2 = 0.96) than VP (r2 = 0.86), indicative of corelease from the neural lobe during chronic dehydration.
    1 context sentence
    Summary · context
    To quantify cytokine depletion from the neural lobe during progressive salt loading and determine whether the changes are reversible and correspond with stores of vasopressin (VP) or oxytocin (OT), rats were given water on day 0 and then 2% NaCl to drink for 2, 5, 8 or 5 days followed by 5 days of water (rehydration).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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