In rat hypothalamus and cerebellum, GHRP‑6 reversed glutamate-induced cell death.
In plain wordsIn rats, GHRP‑6 reduced glutamate-induced cell death in the hypothalamus and cerebellum.
- Peptide
- GHRP-6
- Outcome
- DecreaseCell death
- Study
ratn: not reported in source
Glutamate-induced hypothalamic and cerebellar injury- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Growth hormone releasing peptide-6 reversed glutamate-induced cell death by decreasing activation of caspases 9 and 7 and poly(ADP-ribose) polymerase fragmentation.
2 context sentences(design, population, supporting numbers)
Glutamate increased activation of caspase 9 followed by cleavage of caspase 7, which in turn fragmented poly(ADP-ribose) polymerase, terminating in cell death in both the hypothalamus and cerebellum.
Because abnormally high concentrations of glutamate can lead to overexcitation of neurones leading to cell damage and/or death, we investigated whether administration of growth hormone releasing peptide-6 attenuates monosodium glutamate-induced apoptosis in the rat hypothalamus and cerebellum.