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Study · Animal study (in vivo) · prairie vole · 2007

4 results

Neonatal oxytocin manipulations have long-lasting, sexually dimorphic effects on vasopressin receptors.

Bales KL, Plotsky PM, Young LJ, Lim MM, Grotte N, Ferrer E, Carter CS

Neuroscience19 Oct 2006Cited by 116 (Europe PMC)

PMID17055176 (opens in a new tab)PMCIDPMC1774559 (opens in a new tab)DOI10.1016/j.neuroscience.2006.09.009 (opens in a new tab)PepBankPUB-17055176
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In prairie voles, neonatal treatment did not significantly change D2 receptor binding.

    In plain wordsIn prairie voles, early treatment did not change dopamine D2 receptor binding.

    Peptide
    Oxytocin
    Outcome
    No significant changeDopamine D2 receptor binding
    Study

    prairie volen: not reported in source

    Neonatal intraperitoneal injection, receptor autoradiography at about 60 days
    Comparator
    Saline vehicle or handling only
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · postnatal day 1As given in this study (prairie vole).

    Source sentences

    Summary
    No significant treatment or sex differences were observed for D2 receptor binding
    1 context sentence
    Summary · context
    On postnatal day 1, prairie voles were injected intraperitoneally with either OT (1 mg/kg), an OTA (0.1 mg/kg), saline vehicle, or were handled only. At approximately 60 days of age, vasopressin V1a receptors, OT receptors (OTR) and dopamine D2 receptor binding were quantified using receptor autorad…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In prairie voles, neonatal treatment did not significantly change oxytocin receptor binding.

    In plain wordsIn prairie voles, early treatment did not change oxytocin receptor binding.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin receptor binding
    Study

    prairie volen: not reported in source

    Neonatal intraperitoneal injection, receptor autoradiography at about 60 days
    Comparator
    Saline vehicle or handling only
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg · intraperitoneal · postnatal day 1As given in this study (prairie vole).

    Source sentences

    Summary
    No significant treatment difference was observed for OTR receptor binding
    1 context sentence
    Summary · context
    On postnatal day 1, prairie voles were injected intraperitoneally with either OT (1 mg/kg), an OTA (0.1 mg/kg), saline vehicle, or were handled only. At approximately 60 days of age, vasopressin V1a receptors, OT receptors (OTR) and dopamine D2 receptor binding were quantified using receptor autorad…

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In prairie voles, neonatal injection of oxytocin or an oxytocin antagonist (compared with saline or handling only) had significant treatment effects on V1a binding in the BNST, cingulate cortex, mediodorsal thalamus, medial preoptic area and lateral septum; the abstract does not say which treatment or which direction.

    In plain wordsIn prairie voles, injections of oxytocin or an oxytocin blocker on the first day of life changed vasopressin receptor binding in several brain areas.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedVasopressin V1a receptor binding
    Study

    prairie volen: not reported in source

    Neonatal intraperitoneal injection, receptor autoradiography at about 60 days
    Comparator
    Saline vehicle or handling only
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Significant treatment effects on V1a binding were found in the bed nucleus of the stria terminalis (BNST), cingulate cortex (CgCtx), mediodorsal thalamus (MdThal), medial preoptic area of the hypothalamus (MPOA), and lateral septum (LS).
    1 context sentence
    Summary · context
    On postnatal day 1, prairie voles were injected intraperitoneally with either OT (1 mg/kg), an OTA (0.1 mg/kg), saline vehicle, or were handled only. At approximately 60 days of age, vasopressin V1a receptors, OT receptors (OTR) and dopamine D2 receptor binding were quantified using receptor autorad…

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In prairie voles, neonatal injection of oxytocin or an oxytocin antagonist produced significant sex by treatment interactions on V1a binding in the cingulate cortex, medial preoptic area, ventral pallidum and lateral septum.

    In plain wordsIn prairie voles, first-day oxytocin or oxytocin blocker changed vasopressin receptor binding differently in males and females in some brain areas.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSex by treatment interaction on V1a binding
    Study

    prairie volen: not reported in source

    Neonatal intraperitoneal injection, receptor autoradiography at about 60 days
    Comparator
    Saline vehicle or handling only
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The CgCtx, MPOA, ventral pallidum, and LS also showed significant sex by treatment interactions on V1a binding.
    1 context sentence
    Summary · context
    On postnatal day 1, prairie voles were injected intraperitoneally with either OT (1 mg/kg), an OTA (0.1 mg/kg), saline vehicle, or were handled only. At approximately 60 days of age, vasopressin V1a receptors, OT receptors (OTR) and dopamine D2 receptor binding were quantified using receptor autorad…

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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