A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices.

Arul V, Kartha R, Jayakumar R

Life sciences23 Sept 2006Cited by 54 (Europe PMC)

PMID17049946DOI10.1016/j.lfs.2006.09.018PepBankPUB-17049946

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

01AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, BioGHK incorporated collagen increased the rate of wound contraction.
In plain wordsIn rats with diabetes, BioGHK incorporated collagen increased wound contraction.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseWound contraction
Study
ratsn: not reported in source
diabetic rats
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
In diabetic rats treated with BioGHK incorporated collagen (Peptide Incorporated Collagen--PIC), the healing process was hastened with an increased rate of wound contraction.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994601
02AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, skin glutathione was higher with PIC than with untreated control.
In plain wordsIn rats with diabetes, skin glutathione was higher with PIC than with untreated control.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseSkin glutathione
Study
ratsn: not reported in source
diabetic rats
Comparator
Untreated control
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Glutathione (GSH) and ascorbic acid levels in the skin of streptozotocin-induced diabetic rats were higher in the PIC group as compared to control (Untreated) and collagen (Collagen Film--CF) treated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994602
03AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, skin glutathione was higher with PIC than with collagen film.
In plain wordsIn rats with diabetes, skin glutathione was higher with PIC than with collagen film.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseSkin glutathione
Study
ratsn: not reported in source
diabetic rats
Comparator
Collagen film
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Glutathione (GSH) and ascorbic acid levels in the skin of streptozotocin-induced diabetic rats were higher in the PIC group as compared to control (Untreated) and collagen (Collagen Film--CF) treated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994603
04AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, skin ascorbic acid was higher with PIC than with untreated control.
In plain wordsIn rats with diabetes, skin ascorbic acid was higher with PIC than with untreated control.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseSkin ascorbic acid
Study
ratsn: not reported in source
diabetic rats
Comparator
Untreated control
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Glutathione (GSH) and ascorbic acid levels in the skin of streptozotocin-induced diabetic rats were higher in the PIC group as compared to control (Untreated) and collagen (Collagen Film--CF) treated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994604
05AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, skin ascorbic acid was higher with PIC than with collagen film.
In plain wordsIn rats with diabetes, skin ascorbic acid was higher with PIC than with collagen film.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseSkin ascorbic acid
Study
ratsn: not reported in source
diabetic rats
Comparator
Collagen film
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Glutathione (GSH) and ascorbic acid levels in the skin of streptozotocin-induced diabetic rats were higher in the PIC group as compared to control (Untreated) and collagen (Collagen Film--CF) treated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994605
06AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, SOD activity changed in all groups, including PIC.
In plain wordsIn rats with diabetes, SOD activity changed in all groups, including PIC.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
Direction not reportedSuperoxide dismutase activity
Study
ratsn: not reported in source
diabetic rats
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Superoxide dismutase (SOD) and catalase (CAT) activity was altered in all the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994606
07AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, CAT activity changed in all groups, including PIC.
In plain wordsIn rats with diabetes, CAT activity changed in all groups, including PIC.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
Direction not reportedCatalase activity
Study
ratsn: not reported in source
diabetic rats
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Superoxide dismutase (SOD) and catalase (CAT) activity was altered in all the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994607
08AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, histology revealed epithelialization in the PIC group.
In plain wordsIn rats with diabetes, histology showed epithelialization in the PIC group.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
Not applicableEpithelialization
Study
ratsn: not reported in source
diabetic rats
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Histological evaluation by haematoxylin-eosin and Masson's trichrome method revealed epithelialization, increased synthesis of collagen and activation of fibroblasts and mast cells in the PIC group.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994609
09AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, histology revealed increased collagen synthesis in the PIC group.
In plain wordsIn rats with diabetes, histology showed increased collagen synthesis in the PIC group.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseCollagen synthesis
Study
ratsn: not reported in source
diabetic rats
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Histological evaluation by haematoxylin-eosin and Masson's trichrome method revealed epithelialization, increased synthesis of collagen and activation of fibroblasts and mast cells in the PIC group.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994610
10AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, histology revealed fibroblast activation in the PIC group.
In plain wordsIn rats with diabetes, histology showed fibroblast activation in the PIC group.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseFibroblast activation
Study
ratsn: not reported in source
diabetic rats
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Histological evaluation by haematoxylin-eosin and Masson's trichrome method revealed epithelialization, increased synthesis of collagen and activation of fibroblasts and mast cells in the PIC group.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994611
11AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, histology revealed mast cell activation in the PIC group.
In plain wordsIn rats with diabetes, histology showed mast cell activation in the PIC group.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseMast cell activation
Study
ratsn: not reported in source
diabetic rats
Outcome group
Immune response · Skin and wound
Source sentences
Summary
Histological evaluation by haematoxylin-eosin and Masson's trichrome method revealed epithelialization, increased synthesis of collagen and activation of fibroblasts and mast cells in the PIC group.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the role of biotinylated GHK peptide (BioGHK) incorporated collagen biomaterial was tested for wound healing in diabetic rats.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994612
12LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Efficacy outcome
In fibroblast cultures, the results suggested that PIC promoted fibroblast growth.
In plain wordsIn cells, the results suggested that PIC promoted fibroblast growth.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseFibroblast growth
Study
n: not reported in source
fibroblast cell culture
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
In vitro fibroblast cell culture studies suggest that PIC promotes fibroblast growth.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1704994608

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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