In healthy volunteers, rectal mucosal expression of cathelicidin LL37 was not changed after isomalt compared with sucrose.
In plain wordsIn healthy adults, isomalt did not change the body's own LL37 gene activity in the rectum compared with sucrose.
- Peptide
- LL-37
- Outcome
- No significant changeRectal mucosal cathelicidin LL37 expression
- Study
n = 19
- Comparator
- Sucrose 30 g per day
- Outcome group
- Immune response · Gastrointestinal
Source sentences
In addition, the expression of cathelicidin LL37, GSTpi, UGT1A1, CYP3A4, COX-2, MUC2 and ZO-1 was not changed in rectal biopsies.
1 context sentence(design, population, supporting numbers)
Nineteen healthy volunteers received 30 g isomalt per day or 30 g sucrose as part of a controlled diet over two 4-week test periods with a 4-week washout period in between.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.