Skip to content

Study · In vitro (cells) · mouse · 2007

5 results

Effects of oxytocin on cardiomyocyte differentiation from mouse embryonic stem cells.

Hatami L, Valojerdi MR, Mowla SJ

International journal of cardiology10 Oct 2006Cited by 34 (Europe PMC)

PMID17034884 (opens in a new tab)DOI10.1016/j.ijcard.2006.04.054 (opens in a new tab)PepBankPUB-17034884
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In mouse embryonic stem cell-derived embryoid bodies, oxytocin increased the percentage with spontaneous contraction from day 17 onward.

    In plain wordsIn mouse stem cells grown in the lab, oxytocin raised the share of cell clusters that beat on their own from day 17.

    Peptide
    Oxytocin
    Outcome
    IncreasePercentage of embryoid bodies with spontaneous contraction
    Study

    mousen: not reported in source

    Mouse embryonic stem cell-derived embryoid bodies
    Comparator
    Embryoid bodies without oxytocin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the experimental group, the percentage of the EBs with spontaneous contraction was significantly increased from 17th day onward.
    1 context sentence
    Summary · context
    Mouse ESCs were cultivated in hanging drops to form embryoid bodies (EBs). The EBs were then treated with and without oxytocin (experimental and control groups).
  2. 02LabIn vitro (cells)Efficacy outcome

    In embryoid bodies treated with oxytocin, beating-rate changes with isoprenaline were more pronounced at the early and intermediate stages of cardiomyocyte development.

    In plain wordsIn mouse stem cell clusters, oxytocin made the beating-rate response to isoprenaline stronger at early and middle stages.

    Peptide
    Oxytocin
    Outcome
    IncreaseChronotropic response to isoprenaline
    Study

    mousen: not reported in source

    Mouse embryonic stem cell-derived embryoid bodies
    Comparator
    Embryoid bodies without oxytocin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in the experimental group, changes with isopernaline were more pronounced at the early and intermediate stages of cardiomyocyte development.
    1 context sentence
    Summary · context
    Mouse ESCs were cultivated in hanging drops to form embryoid bodies (EBs). The EBs were then treated with and without oxytocin (experimental and control groups).
  3. 03LabIn vitro (cells)Efficacy outcome

    In mouse embryonic stem cell-derived cardiomyocytes, oxytocin did not change ultrastructural features compared with untreated cells.

    In plain wordsIn mouse stem cell-derived heart cells, oxytocin did not change the fine cell structure compared with untreated cells.

    Peptide
    Oxytocin
    Outcome
    No significant changeUltrastructure of derived cardiomyocytes
    Study

    mousen: not reported in source

    Mouse embryonic stem cell-derived embryoid bodies
    Comparator
    Embryoid bodies without oxytocin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The beating cells of both groups, stained positive with anti alpha-actinin, desmin, cardiac troponin I and connexin antibodies, and revealed similar ultrastructural features.
    1 context sentence
    Summary · context
    Mouse ESCs were cultivated in hanging drops to form embryoid bodies (EBs). The EBs were then treated with and without oxytocin (experimental and control groups).
  4. 04LabIn vitro (cells)Mechanism

    In oxytocin-treated embryoid bodies, cardiac-specific genes, except alpha-myosin heavy chain, were more pronounced at the early stage of cardiomyocyte development.

    In plain wordsIn mouse stem cell clusters, oxytocin raised heart-specific gene activity early in development, apart from one gene.

    Peptide
    Oxytocin
    Outcome
    IncreaseCardiac-specific gene expression
    Study

    mousen: not reported in source

    Mouse embryonic stem cell-derived embryoid bodies
    Comparator
    Embryoid bodies without oxytocin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the experimental group, all the specific genes, with the exception of alpha-myosin heavy chain, were more pronounced at the early stage of cardiomyocyte development.
    1 context sentence
    Summary · context
    Mouse ESCs were cultivated in hanging drops to form embryoid bodies (EBs). The EBs were then treated with and without oxytocin (experimental and control groups).

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 05LabNot a test of Oxytocin aloneIn vitro (cells)Mechanism

    Oxytocin receptors were detected on mouse undifferentiated embryonic stem cells and on derived differentiated cells.

    In plain wordsIn mouse stem cells and the cells made from them, oxytocin receptors were found.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor presence on stem cells and derived cells
    Study

    mousen: not reported in source

    Mouse embryonic stem cell-derived embryoid bodies
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Oxytocin receptors were detected on the ESCs and derived-differentiated cells.
    1 context sentence
    Summary · context
    Mouse ESCs were cultivated in hanging drops to form embryoid bodies (EBs). The EBs were then treated with and without oxytocin (experimental and control groups).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.