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Study · Not a test of the peptide alone · 2006

2 results

Involvement of estrogen receptor alpha, beta and oxytocin in social discrimination: A detailed behavioral analysis with knockout female mice.

Choleris E, Ogawa S, Kavaliers M, Gustafsson JA, Korach KS, Muglia LJ, Pfaff DW

Genes, brain, and behavior1 Oct 2006Cited by 130 (Europe PMC)

PMID17010099 (opens in a new tab)DOI10.1111/j.1601-183x.2006.00203.x (opens in a new tab)PepBankPUB-17010099
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In female mice, oxytocin gene knockout completely impaired social discrimination in the binary choice paradigm compared with wild-type controls.

    In plain wordsIn female mice, animals lacking the oxytocin gene could not tell a familiar mouse from a new one, unlike normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseSocial discrimination in oxytocin knockout female mice
    Study

    mousen: not reported in source

    Comparator
    Wild-type controls
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Differently from their wild-type controls, when given a choice, the KO mice showed either reduced (beta-ERKO) or completely impaired (OTKO and alpha-ERKO) social discrimination.
    1 context sentence
    Summary · context
    Here, we used alpha-ERKO, beta-ERKO, and OTKO female mice in the binary social discrimination paradigm.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In female mice, all knockout lines, oxytocin knockout included, had reduced anxiety-related stretched approaches to the social stimulus, with no overall impairment in activity.

    In plain wordsIn female mice, animals lacking the oxytocin gene showed fewer anxiety-related approach movements, with normal general activity.

    Peptide
    Oxytocin
    Outcome
    DecreaseAnxiety-related stretched approaches in knockout mice
    Study

    mousen: not reported in source

    Comparator
    Wild-type controls
    Outcome group
    Anxiety and mood · Nervous system and cognition

    Source sentences

    Summary
    Detailed behavioral analyses indicate that all of the KO mice have reduced anxiety-related stretched approaches to the social stimulus with no overall impairment in horizontal and vertical activity, non-social investigation, and various other behaviors such as, self-grooming, digging, and inactivity.
    1 context sentence
    Summary · context
    Here, we used alpha-ERKO, beta-ERKO, and OTKO female mice in the binary social discrimination paradigm.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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