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Study · Not a test of the peptide alone · 2003

5 results

The influence of serum cortisol levels on growth hormone responsiveness to GH-releasing hormone plus GH-releasing peptide-6 in patients with hypocortisolism.

Pekic S, Doknic M, Djurovic M, Damjanovic S, Petakov M, Miljic D, Dieguez C, Casanueva FF, Popovic V

Hormones (Athens, Greece)1 Oct 2003Cited by 6 (Europe PMC)

PMID17003023 (opens in a new tab)DOI10.14310/horm.2002.11106 (opens in a new tab)PepBankPUB-17003023
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In Addison's disease, GH peaks after GHRH plus GHRP‑6 did not differ from controls.

    In plain wordsIn Addison's disease, GH responses after the combined test did not differ from healthy controls.

    Peptide
    GHRP-6
    Outcome
    No significant changeAddison GH response versus controls
    Study

    n = 24

    Comparator
    Healthy controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    68.2 microg/L
    Addison patients during glucocorticoid therapy, mean (SE 12.8)
    GH peak
    60.3 microg/L
    Addison patients off glucocorticoid therapy, mean (SE 14.1)
    GH peak
    61.5 microg/L
    healthy controls, mean (SE 6.0)

    Source sentences

    Summary
    In the 10 patients with Addison's disease, GH responses (GH peak, microg/L) to GHRH+GHRP-6 were similar both during GC, (68.2+/-12.8) and off GC (60.3+/-14.1) therapy and did not differ from those in controls (61.5+/-6.0).
    1 context sentence
    Summary · context
    We studied 12 patients with hypocortisolism (10 with Addison's disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared them with 14 healthy subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In Addison's disease, GH peaks after GHRH plus GHRP‑6 were similar during and off glucocorticoid replacement.

    In plain wordsIn Addison's disease, GH responses after the combined test were similar with and without glucocorticoid replacement.

    Peptide
    GHRP-6
    Outcome
    No significant changeAddison GH response on versus off replacement
    Study

    n = 10

    Comparator
    Off glucocorticoids
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    68.2 microg/L
    Addison patients during glucocorticoid therapy, mean (SE 12.8)
    GH peak
    60.3 microg/L
    Addison patients off glucocorticoid therapy, mean (SE 14.1)

    Source sentences

    Summary
    In the 10 patients with Addison's disease, GH responses (GH peak, microg/L) to GHRH+GHRP-6 were similar both during GC, (68.2+/-12.8) and off GC (60.3+/-14.1) therapy and did not differ from those in controls (61.5+/-6.0).
    1 context sentence
    Summary · context
    We studied 12 patients with hypocortisolism (10 with Addison's disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared them with 14 healthy subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In newly diagnosed Addison's patients, mean GH peak after GHRH plus GHRP‑6 increased after glucocorticoid replacement.

    In plain wordsIn newly diagnosed Addison's patients, combined-test GH peaks increased after glucocorticoid replacement compared with pretreatment.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH peak after replacement in newly diagnosed patients
    Study

    n = 4

    Comparator
    Before replacement
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    26.4 microg/L
    newly diagnosed Addison patients before glucocorticoid replacement, mean (SE 4.1)
    GH peak
    40.7 microg/L
    newly diagnosed Addison patients after one month of glucocorticoid replacement, mean (SE 11.8)

    Source sentences

    Summary
    In the newly diagnosed Addison's patients, after one month of GC replacement, mean GH peak value increased to 40.7+/-11.8.
    2 context sentences
    Summary · context
    In a subgroup of 4 patients with newly diagnosed Addison's disease, GH responsiveness to GHRH+GHRP-6 prior to GC replacement (26.4+/-4.1) was significantly lower than in the 6 patients with long-standing Addison's disease after short-term GC withdrawal (82.9+/-18.2).
    Summary · context
    We studied 12 patients with hypocortisolism (10 with Addison's disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared them with 14 healthy subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In isolated ACTH deficiency, GH responses to GHRH plus GHRP‑6 did not differ off and on glucocorticoids.

    In plain wordsIn isolated ACTH deficiency, combined-test GH responses did not differ with and without glucocorticoids.

    Peptide
    GHRP-6
    Outcome
    No significant changeACTH deficiency GH response
    Study

    n = 2

    Comparator
    Off glucocorticoids
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    60.3 microg/L
    2 patients with isolated ACTH deficiency off glucocorticoid therapy, mean (SE 14.1)
    GH peak
    41.5 microg/L
    2 patients with isolated ACTH deficiency on glucocorticoid therapy, mean (SE 2.0)

    Source sentences

    Summary
    In the 2 patients with isolated ACTH deficiency, GH responses to GHRH+GHRP-6 did not differ off and on GC therapy (60.3+/-14.1 and 41.5+/-2.0, respectively).
    1 context sentence
    Summary · context
    We studied 12 patients with hypocortisolism (10 with Addison's disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared them with 14 healthy subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  5. 05HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    Newly diagnosed Addison's patients had lower GH peaks after GHRH plus GHRP‑6 than longstanding patients after short-term glucocorticoid withdrawal.

    In plain wordsNewly diagnosed Addison's patients had lower combined-test GH peaks than longstanding patients after short-term glucocorticoid withdrawal.

    Peptide
    GHRP-6
    Outcome
    DecreaseNew versus longstanding Addison GH response
    Study

    n = 10

    Comparator
    Longstanding Addison's disease after glucocorticoid withdrawal
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    26.4 microg/L
    4 newly diagnosed Addison patients before glucocorticoid replacement, mean (SE 4.1)
    GH peak
    82.9 microg/L
    6 long-standing Addison patients after short-term glucocorticoid withdrawal, mean (SE 18.2)

    Source sentences

    Summary
    In a subgroup of 4 patients with newly diagnosed Addison's disease, GH responsiveness to GHRH+GHRP-6 prior to GC replacement (26.4+/-4.1) was significantly lower than in the 6 patients with long-standing Addison's disease after short-term GC withdrawal (82.9+/-18.2).
    1 context sentence
    Summary · context
    We studied 12 patients with hypocortisolism (10 with Addison's disease and 2 with isolated ACTH deficiency) before and after glucocorticoid (GC) replacement therapy and compared them with 14 healthy subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

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