Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.

Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J

Brain research22 Sept 2006Cited by 29 (Europe PMC)

PMID16996037DOI10.1016/j.brainres.2006.07.108PepBankPUB-16996037

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In the rat hippocampus, a single application of Semax produced a maximal 1.4-fold increase in BDNF protein levels.
In plain wordsIn rats, one dose of Semax raised the amount of BDNF protein in the hippocampus by up to 1.4 times.
Peptide
Semax
Outcome
IncreaseHippocampal BDNF protein level
Study
ratn: not reported in source
In vivo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 microg/kg body weight · single applicationAs given in this study (rat).
Measurements
BDNF protein, maximal fold increase
1.4-fold
rat hippocampus
Source sentences
Summary
a maximal 1.4-fold increase of BDNF protein levels
1 context sentence(design, population, supporting numbers)
Summary · context
a single application of Semax (50 microg/kg body weight)
Report a problemFND-1699603701
02AnimalAnimal study (in vivo)Mechanism
In the rat hippocampus, a single application of Semax was accompanied by a 1.6-fold increase in trkB tyrosine phosphorylation levels.
In plain wordsIn rats, one dose of Semax raised trkB activation in the hippocampus by about 1.6 times.
Peptide
Semax
Outcome
IncreaseHippocampal trkB tyrosine phosphorylation
Study
ratn: not reported in source
In vivo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 microg/kg body weight · single applicationAs given in this study (rat).
Measurements
trkB tyrosine phosphorylation, fold increase
1.6-fold
rat hippocampus
Source sentences
Summary
1.6-fold increase of trkB tyrosine phosporylation levels
1 context sentence(design, population, supporting numbers)
Summary · context
a single application of Semax (50 microg/kg body weight)
Report a problemFND-1699603702
03AnimalAnimal study (in vivo)Mechanism
In the rat hippocampus, a single application of Semax produced a 3-fold increase in exon III BDNF mRNA levels.
In plain wordsIn rats, one dose of Semax raised BDNF messenger RNA in the hippocampus about 3 times.
Peptide
Semax
Outcome
IncreaseHippocampal exon III BDNF mRNA level
Study
ratn: not reported in source
In vivo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 microg/kg body weight · single applicationAs given in this study (rat).
Measurements
exon III BDNF mRNA, fold increase
3-fold
rat hippocampus
Source sentences
Summary
a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus
1 context sentence(design, population, supporting numbers)
Summary · context
a single application of Semax (50 microg/kg body weight)
Report a problemFND-1699603703
04AnimalAnimal study (in vivo)Mechanism
In the rat hippocampus, a single application of Semax produced a 2-fold increase in trkB mRNA levels.
In plain wordsIn rats, one dose of Semax raised trkB messenger RNA in the hippocampus about 2 times.
Peptide
Semax
Outcome
IncreaseHippocampal trkB mRNA level
Study
ratn: not reported in source
In vivo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 microg/kg body weight · single applicationAs given in this study (rat).
Measurements
trkB mRNA, fold increase
2-fold
rat hippocampus
Source sentences
Summary
a 3-fold and a 2-fold increase of exon III BDNF and trkB mRNA levels, respectively, in the rat hippocampus
1 context sentence(design, population, supporting numbers)
Summary · context
a single application of Semax (50 microg/kg body weight)
Report a problemFND-1699603704
05AnimalAnimal study (in vivo)Efficacy outcome
Semax-treated rats showed a distinct increase in the number of conditioned avoidance reactions.
In plain wordsIn rats, Semax treatment increased the number of learned avoidance reactions.
Peptide
Semax
Outcome
IncreaseConditioned avoidance reactions
Study
ratn: not reported in source
In vivo
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Semax-treated animals showed a distinct increase in the number of conditioned avoidance reactions.
Report a problemFND-1699603705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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