In rats with brain ischemia, noopept reduced infarction area by 34.5% versus saline.
In plain wordsIn rats with brain ischemia, noopept reduced damaged brain area compared with saline.
- Peptide
- Noopept (omberacetam)
- Outcome
- DecreaseCortical infarction area
- Study
ratn: not reported in source
Middle cerebral artery occlusion with ipsilateral common carotid artery ligation- Comparator
- Saline
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 0.5 mg/kg · intraperitoneal · 15 min and 2, 24, and 48 h after occlusionAs given in this study (rat).
Measurements
- Brain damage
- 18.6%
- saline
- Brain damage
- 12.2%
- noopept
- Infarction area reduction
- 34.5%
- versus saline
Source sentences
The extent of the brain damage in control group (treated by saline) was 18.6%, while that in the group treated with noopept was 12.2%, thus demonstrating a decrease in the infarction area by 34.5% (p < 05).
2 context sentences(design, population, supporting numbers)
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) on the extent of ischemic cortical stroke was investigated in experiments on white mongrel male rats with ischemia induced by a combination of the middle cerebral artery occlusion with ipsilateral common carotid artery ligation.
Animals were treated with noopept (0.5 mg/kg, i.p.) according to the following schedule: 15 min and 2, 24, and 48 h after the occlusion.