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Study · Animal study (in vivo) · pig · 2007

10 results

Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction.

Berlanga J, Cibrian D, Guevara L, Dominguez H, Alba JS, Seralena A, Guillén G, López-Mola E, López-Saura P, Rodriguez A, Perez B, Garcia D, Vispo NS

Clinical science (London, England : 1979)1 Feb 2007Cited by 17 (Europe PMC)

PMID16989643 (opens in a new tab)DOI10.1042/cs20060103 (opens in a new tab)PepBankPUB-16989643
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In pigs with coronary occlusion, GHRP6 did not influence intraoperative mortality associated with rhythm and conductance disturbances.

    In plain wordsIn pigs with coronary occlusion, GHRP6 did not change deaths during surgery compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeIntraoperative mortality
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    GHRP6 treatment did not have any influence on mortality during surgery associated with rhythm and conductance disturbances during ischaemia.
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with acute myocardial infarction, GHRP6 reduced infarct mass by 78% versus saline.

    In plain wordsIn pigs with acute heart injury, GHRP6 reduced infarct mass by 78% compared with saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseInfarct mass
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Measurements

    Infarct mass reduction
    78%
    GHRP6 versus saline

    Source sentences

    Summary
    Infarct mass and thickness were reduced by 78% and 50% respectively, by GHRP6 compared with saline (P<0.01).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with acute myocardial infarction, GHRP6 reduced infarct thickness by 50% versus saline.

    In plain wordsIn pigs with acute heart injury, GHRP6 reduced infarct thickness by 50% compared with saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseInfarct thickness
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Measurements

    Infarct thickness reduction
    50%
    GHRP6 versus saline

    Source sentences

    Summary
    Infarct mass and thickness were reduced by 78% and 50% respectively, by GHRP6 compared with saline (P<0.01).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In GHRP6-treated pigs with coronary occlusion, more than 50% had no pathological Q waves in any ECG lead.

    In plain wordsIn GHRP6-treated pigs with coronary occlusion, more than 50% had no pathological Q waves on their ECG.

    Peptide
    GHRP-6
    Outcome
    Not applicableAbsence of pathological Q waves
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Measurements

    Pigs without pathological Q waves
    > 50%
    GHRP6-treated pigs

    Source sentences

    Summary
    More than 50% of the GHRP6-treated pigs did not exhibit pathogological Q waves in any of the ECG leads.
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with coronary occlusion, quantitative histopathology confirmed reduced myocardial necrosis with GHRP6 versus saline.

    In plain wordsIn pigs with coronary occlusion, tissue examination confirmed less heart tissue death with GHRP6 than saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseHistopathological myocardial necrosis
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    Quantitative histopathology and CK-MB and CRP serum levels confirmed the reduction in GHRP6-mediated necrosis (all P<0.05).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with coronary occlusion, serum CK-MB supported reduced necrosis with GHRP6 versus saline.

    In plain wordsIn pigs with coronary occlusion, serum CK-MB supported less heart tissue death with GHRP6 than saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseSerum CK-MB
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    Quantitative histopathology and CK-MB and CRP serum levels confirmed the reduction in GHRP6-mediated necrosis (all P<0.05).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with coronary occlusion, serum CRP supported reduced necrosis with GHRP6 versus saline.

    In plain wordsIn pigs with coronary occlusion, serum CRP supported less heart tissue death with GHRP6 than saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseSerum CRP
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    Quantitative histopathology and CK-MB and CRP serum levels confirmed the reduction in GHRP6-mediated necrosis (all P<0.05).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In pigs with coronary occlusion, oxidative stress markers suggested that GHRP6 reduced reactive oxygen species versus saline.

    In plain wordsIn pigs with coronary occlusion, markers suggested that GHRP6 reduced reactive oxygen species compared with saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseReactive oxygen species
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    Levels of oxidative stress markers suggested that GHRP6 prevented myocardial injury via a decrease in reactive oxygen species and by the preservation of antioxidant defence systems (all P<0.05).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In pigs with coronary occlusion, oxidative stress markers suggested that GHRP6 preserved antioxidant defence systems versus saline.

    In plain wordsIn pigs with coronary occlusion, markers suggested that GHRP6 preserved antioxidant defences compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseAntioxidant defence preservation
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    Levels of oxidative stress markers suggested that GHRP6 prevented myocardial injury via a decrease in reactive oxygen species and by the preservation of antioxidant defence systems (all P<0.05).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In pigs, GHRP6 did not amplify myocardial IGF-I transcription beyond the increase induced by ischaemia.

    In plain wordsIn pigs, GHRP6 did not increase heart IGF-I gene activity beyond the rise caused by ischaemia.

    Peptide
    GHRP-6
    Outcome
    No significant changeMyocardial IGF-I transcription
    Study

    pign: not reported in source

    Acute coronary occlusion and reperfusion in female Cuban Creole pigs
    Comparator
    Normal saline
    Outcome group
    Growth hormone and IGF-1 · Cardiovascular
    Studied dose
    400 microg/kg of body weightAs given in this study (pig).

    Source sentences

    Summary
    Myocardial IGF-I transcription was not amplified by GHRP6 treatment compared with the increase induced by the ischaemic episode in relation to expression in intact hearts (P<0.01).
    2 context sentences
    Summary · context
    Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period.
    Summary · context
    Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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