In a matrigel network formation assay, studies with the non-IGFBP-binding IGF-1 analog Long-R3 showed that IGFBP-3 inhibition of vascular network formation is primarily IGF independent.
In plain wordsIn lab tests on blood vessel cells, studies using Long-R3 showed that IGFBP-3 blocks vessel network formation mostly without IGF.
- Peptide
- IGF-1 LR3
- Outcome
- Not applicableIGF dependence of IGFBP-3 inhibition of network formation
- Study
humann: not reported in source
HUVEC network formation assay- Outcome group
- Receptor activity and mechanism · Cancer
Source sentences
This action is primarily IGF independent as shown by studies utilizing the non-IGFBP-binding IGF-1 analog Long-R3.
1 context sentence(design, population, supporting numbers)
In vitro, IGFBP-3 inhibited both vascular endothelial growth factor- and IGF-stimulated human umbilical vein endothelial cells vascular network formation in a matrigel assay.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.