Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength.

Fox J, Miller MA, Newman MK, Metcalfe AF, Turner CH, Recker RR, Smith SY

Calcified tissue international11 Sept 2006Cited by 50 (Europe PMC)

PMID16969596DOI10.1007/s00223-006-0108-1PepBankPUB-16969596

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study21

21 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH restored lumbar spine BMD to sham levels within 6 months and maintained gains through 12 months.
In plain wordsIn aged ovariectomized rats, PTH restored spine bone density to sham levels and maintained the gain.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeLumbar spine BMD restoration
Study
ratn: not reported in source
Aged ovariectomized rats
Comparator
Sham animals
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
The 15 microg/kg dose of PTH restored BMD to levels similar to those in sham animals within 6 months at the lumbar spine, distal and central femur, and whole body and maintained the BMD gain from 6 to 12 months.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959601
02AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH restored distal femur BMD to sham levels within 6 months and maintained gains through 12 months.
In plain wordsIn aged ovariectomized rats, PTH restored distal femur bone density to sham levels and maintained the gain.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeDistal femur BMD restoration
Study
ratn: not reported in source
Aged ovariectomized rats
Comparator
Sham animals
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
The 15 microg/kg dose of PTH restored BMD to levels similar to those in sham animals within 6 months at the lumbar spine, distal and central femur, and whole body and maintained the BMD gain from 6 to 12 months.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959602
03AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH restored central femur BMD to sham levels within 6 months and maintained gains through 12 months.
In plain wordsIn aged ovariectomized rats, PTH restored central femur bone density to sham levels and maintained the gain.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeCentral femur BMD restoration
Study
ratn: not reported in source
Aged ovariectomized rats
Comparator
Sham animals
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
The 15 microg/kg dose of PTH restored BMD to levels similar to those in sham animals within 6 months at the lumbar spine, distal and central femur, and whole body and maintained the BMD gain from 6 to 12 months.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959603
04AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH restored whole-body BMD to sham levels within 6 months and maintained gains through 12 months.
In plain wordsIn aged ovariectomized rats, PTH restored whole-body bone density to sham levels and maintained the gain.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeWhole-body BMD restoration
Study
ratn: not reported in source
Aged ovariectomized rats
Comparator
Sham animals
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
The 15 microg/kg dose of PTH restored BMD to levels similar to those in sham animals within 6 months at the lumbar spine, distal and central femur, and whole body and maintained the BMD gain from 6 to 12 months.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959604
05AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH at 30 microg/kg produced greater BMD effects than the lower dose.
In plain wordsIn aged ovariectomized rats, the higher PTH dose produced greater bone density effects than the lower dose.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseHigher-dose BMD effect
Study
ratn: not reported in source
Aged ovariectomized rats
Comparator
15 microg/kg
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
The 30 microg/kg dose produced greater effects.
2 context sentences(design, population, supporting numbers)
Summary · context
The 15 microg/kg dose of PTH restored BMD to levels similar to those in sham animals within 6 months at the lumbar spine, distal and central femur, and whole body and maintained the BMD gain from 6 to 12 months.
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959605
06AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, both PTH doses normalized lumbar vertebral BV/TV.
In plain wordsIn aged ovariectomized rats, both PTH doses restored the vertebral trabecular bone volume ratio.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseLumbar vertebral BV/TV
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 or 30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
Both PTH doses normalized the trabecular bone volume-to-total volume ratio (BV/TV) at lumbar vertebra 3 but not at the proximal tibia (where baseline BV/TV was very low), solely by increasing trabecular thickness.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959606
07AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, neither PTH dose normalized proximal tibial BV/TV, where baseline values were very low.
In plain wordsIn aged ovariectomized rats, neither PTH dose restored the proximal tibial trabecular bone volume ratio.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Direction not reportedProximal tibial BV/TV
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 or 30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
Both PTH doses normalized the trabecular bone volume-to-total volume ratio (BV/TV) at lumbar vertebra 3 but not at the proximal tibia (where baseline BV/TV was very low), solely by increasing trabecular thickness.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959607
08AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, both PTH doses increased trabecular thickness.
In plain wordsIn aged ovariectomized rats, both PTH doses increased trabecular thickness.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseTrabecular thickness
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 or 30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
Both PTH doses normalized the trabecular bone volume-to-total volume ratio (BV/TV) at lumbar vertebra 3 but not at the proximal tibia (where baseline BV/TV was very low), solely by increasing trabecular thickness.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959608
09AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH dose-dependently increased bone formation.
In plain wordsIn aged ovariectomized rats, PTH increased bone formation with increasing dose.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseBone formation
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 or 30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH dose-dependently increased bone formation by increasing the mineralizing surface, but only the 30 microg/kg dose increased resorption.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959609
10AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH increased mineralizing surface.
In plain wordsIn aged ovariectomized rats, PTH increased the bone surface undergoing mineralization.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseMineralizing surface
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 or 30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH dose-dependently increased bone formation by increasing the mineralizing surface, but only the 30 microg/kg dose increased resorption.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959610
11AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, the lower PTH dose did not increase bone resorption.
In plain wordsIn aged ovariectomized rats, the lower PTH dose did not increase bone resorption.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeBone resorption at lower dose
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
15 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH dose-dependently increased bone formation by increasing the mineralizing surface, but only the 30 microg/kg dose increased resorption.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959611
12AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, only the higher PTH dose increased bone resorption.
In plain wordsIn aged ovariectomized rats, only the higher PTH dose increased bone resorption.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseBone resorption at higher dose
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 microg/kg daily · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH dose-dependently increased bone formation by increasing the mineralizing surface, but only the 30 microg/kg dose increased resorption.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959612
13AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH increased cortical BMD.
In plain wordsIn aged ovariectomized rats, PTH increased cortical bone density.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseCortical BMD
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased cortical BMD, area, and thickness, primarily by increasing endocortical bone formation, and restored all measures of bone strength to levels similar to those in sham animals at all skeletal sites.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959613
14AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH increased cortical area.
In plain wordsIn aged ovariectomized rats, PTH increased cortical bone area.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseCortical area
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased cortical BMD, area, and thickness, primarily by increasing endocortical bone formation, and restored all measures of bone strength to levels similar to those in sham animals at all skeletal sites.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959614
15AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH increased cortical thickness.
In plain wordsIn aged ovariectomized rats, PTH increased cortical thickness.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseCortical thickness
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased cortical BMD, area, and thickness, primarily by increasing endocortical bone formation, and restored all measures of bone strength to levels similar to those in sham animals at all skeletal sites.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959615
16AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH increased endocortical bone formation.
In plain wordsIn aged ovariectomized rats, PTH increased bone formation along the inner cortical surface.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseEndocortical bone formation
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased cortical BMD, area, and thickness, primarily by increasing endocortical bone formation, and restored all measures of bone strength to levels similar to those in sham animals at all skeletal sites.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959616
17AnimalAnimal study (in vivo)Efficacy outcome
In aged ovariectomized rats, PTH restored all bone strength measures to sham levels at all skeletal sites.
In plain wordsIn aged ovariectomized rats, PTH restored bone strength to sham levels at all measured sites.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeBone strength restoration
Study
ratn: not reported in source
Aged ovariectomized rats
Comparator
Sham animals
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased cortical BMD, area, and thickness, primarily by increasing endocortical bone formation, and restored all measures of bone strength to levels similar to those in sham animals at all skeletal sites.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959617
18AnimalAnimal study (in vivo)Safety outcome
In aged ovariectomized rats given PTH, no osteoid accumulation occurred.
In plain wordsIn aged ovariectomized rats given PTH, no osteoid accumulation occurred.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Not applicableOsteoid accumulation
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Adverse events · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased bone mass safely; there was no osteoid accumulation, mineralization defect, or marrow fibrosis and there were no abnormal cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959618
19AnimalAnimal study (in vivo)Safety outcome
In aged ovariectomized rats given PTH, no mineralization defect occurred.
In plain wordsIn aged ovariectomized rats given PTH, no mineralization defect occurred.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Not applicableMineralization defect
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Adverse events · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased bone mass safely; there was no osteoid accumulation, mineralization defect, or marrow fibrosis and there were no abnormal cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959619
20AnimalAnimal study (in vivo)Safety outcome
In aged ovariectomized rats given PTH, no marrow fibrosis occurred.
In plain wordsIn aged ovariectomized rats given PTH, no marrow fibrosis occurred.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Not applicableMarrow fibrosis
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Adverse events · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased bone mass safely; there was no osteoid accumulation, mineralization defect, or marrow fibrosis and there were no abnormal cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959620
21AnimalAnimal study (in vivo)Safety outcome
In aged ovariectomized rats given PTH, no abnormal cells occurred.
In plain wordsIn aged ovariectomized rats given PTH, no abnormal cells occurred.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Not applicableAbnormal cells
Study
ratn: not reported in source
Aged ovariectomized rats
Outcome group
Adverse events · Musculoskeletal
Studied dose
Dose not stated · 12 monthsAs given in this study (rat).
Source sentences
Summary
PTH increased bone mass safely; there was no osteoid accumulation, mineralization defect, or marrow fibrosis and there were no abnormal cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used densitometry, histomorphometry, and biomechanical testing to evaluate the effects of 12-month daily treatment with low-dose PTH (15 or 30 microg/kg) in rats that were 10 months old at baseline, 4 months after OVX.
Report a problemFND-1696959621

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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