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Study · Animal study (in vivo) · rabbit · 2006

4 results

Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide.

Bonfiglio V, Camillieri G, Avitabile T, Leggio GM, Drago F

Experimental eye research11 Sept 2006Cited by 27 (Europe PMC)

PMID16965771 (opens in a new tab)DOI10.1016/j.exer.2006.07.014 (opens in a new tab)PepBankPUB-16965771
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with corneal epithelial abrasion, topical KPV significantly reduced the percent of epithelial defect remaining compared with controls.

    In plain wordsIn rabbits with a scraped cornea, KPV eye drops left a smaller unhealed area than the control drops.

    Peptide
    KPV
    Outcome
    DecreasePercent corneal epithelial defect remaining
    Study

    rabbitn: not reported in source

    Mechanical corneal epithelial abrasion
    Comparator
    Vehicle (phosphate-buffered saline)
    Outcome group
    Wound healing · Eye
    Studied dose
    1, 5 or 10 mg/ml · topical · 4 daysAs given in this study (rabbit).

    Source sentences

    Summary
    The mean percent epithelial defect remaining each time was significantly smaller in animals treated with KPV or SP in comparison to controls.
    2 context sentences
    Summary · context
    Rabbits were topically treated with KPV 1, 5 or 10 mg/ml (30 microl), two drops four times in a day, for 4 days, starting immediately after corneal abrasion, while control animals received topical phosphate-buffered saline as vehicle.
    Summary · context
    The whole corneal epithelium was denuded in both eyes by mechanical abrasion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with corneal epithelial abrasion, all eight corneas treated with KPV or SP were completely re-epithelized at sixty hours, and none of the placebo corneas were.

    In plain wordsIn rabbits with a scraped cornea, all eight corneas treated with KPV or a nitric oxide donor healed by sixty hours; none given placebo did.

    Peptide
    KPV
    Outcome
    IncreaseComplete corneal re-epithelialization at sixty hours
    Study

    rabbitn: not reported in source

    Mechanical corneal epithelial abrasion
    Comparator
    Placebo
    Outcome group
    Wound healing · Eye
    Studied dose
    1, 5 or 10 mg/ml · topical · 4 daysAs given in this study (rabbit).

    Measurements

    Corneas completely re-epithelized
    100%
    KPV or SP at sixty hours

    Source sentences

    Summary
    Sixty hours later, eight out of eight (100%) corneas treated with KPV or SP were completely re-epithelized (P<0.05) while none of the corneas treated with placebo were re-epithelized.
    2 context sentences
    Summary · context
    Rabbits were topically treated with KPV 1, 5 or 10 mg/ml (30 microl), two drops four times in a day, for 4 days, starting immediately after corneal abrasion, while control animals received topical phosphate-buffered saline as vehicle.
    Summary · context
    The whole corneal epithelium was denuded in both eyes by mechanical abrasion.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rabbits, pre-treatment with the nitric oxide synthase inhibitor L-NAME inhibited the facilitating effect of KPV on corneal epithelial wound healing.

    In plain wordsIn rabbits, blocking nitric oxide production with L-NAME stopped KPV from speeding up corneal healing, which points to a role for nitric oxide.

    Peptide
    KPV
    Outcome
    Not applicableEffect of nitric oxide synthase inhibitor L-NAME on KPV-facilitated wound healing
    Study

    rabbitn: not reported in source

    Mechanical corneal epithelial abrasion
    Comparator
    KPV without L-NAME
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated · topical · 4 daysAs given in this study (rabbit).

    Source sentences

    Summary
    Pre-treatment with L-NAME inhibited the facilitating effect of KPV on corneal epithelial wound healing process and totally prevented the effect of SP.
    2 context sentences
    Summary · context
    The effects of KPV or SP were challenged by pre-treatment with the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME, 10 mg/ml, 30 microl) 30 min prior to KPV or SP instillation.
    Summary · context
    The whole corneal epithelium was denuded in both eyes by mechanical abrasion.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured rabbit corneal epithelial cells, KPV at 1 and 10 microM stimulated cell viability.

    In plain wordsIn rabbit corneal cells grown in the lab, KPV at 1 and 10 microM increased cell viability.

    Peptide
    KPV
    Outcome
    IncreaseRabbit corneal epithelial cell viability
    Study

    rabbitn: not reported in source

    Rabbit corneal epithelial cells in culture
    Outcome group
    Wound healing · Eye
    Studied dose
    1 and 10 microM · 1, 6 and 24 hAs given in this study (rabbit).

    Source sentences

    Summary
    Cell viability was stimulated by 1 and 10 microM concentrations of the substance.
    1 context sentence
    Summary · context
    Rabbit corneal epithelial cells (RCE) in culture were exposed for 1, 6 and 24 h to different KPV concentrations (0.1, 1 and 10 microM) in medium containing 15% foetal bovine serum (FBS).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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