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Study · Not a test of the peptide alone · 2006

4 results

Sodium ingestion in oxytocin knockout mice.

Vollmer RR, Li X, Karam JR, Amico JA

Experimental neurology23 Aug 2006Cited by 10 (Europe PMC)

PMID16930592 (opens in a new tab)DOI10.1016/j.expneurol.2006.07.006 (opens in a new tab)PepBankPUB-16930592
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In C57BL/6 mice, oxytocin knockout and wild-type mice showed equivalent taste aversion for continuously available NaCl.

    In plain wordsIn mice, animals without oxytocin showed the same dislike of salt water as normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeTaste aversion to 0.2, 0.3 and 0.5 M NaCl
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    In this study, we determined that OT KO and WT mice of C57BL/6 strain demonstrate an equivalent taste aversion for continuously available 0.2 M, 0.3 M or 0.5 M NaCl.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In C57BL/6 mice, oxytocin knockout and wild-type animals ingested the same daily amounts of low, regular and high NaCl diets.

    In plain wordsIn mice, animals without oxytocin ate the same amounts of low, regular and high salt diets as normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeDaily intake of low, regular and high NaCl diets
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Furthermore, OT KO and WT animals ingested the same daily amounts of a low, 0.01%, regular, 1.0%, and a high, 8.0%, NaCl diet that was provided ad libitum as a single choice.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In C57BL/6 mice, both oxytocin knockout and wild-type mice decreased saline consumption to an equal degree as dietary NaCl increased.

    In plain wordsIn mice, animals without oxytocin cut their salt water drinking as much as normal mice when diet salt rose.

    Peptide
    Oxytocin
    Outcome
    No significant changeSaline consumption as dietary NaCl increased
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    As the amount of NaCl in the diet increased, mice of both genotypes significantly decreased the consumption of saline solution to an equal degree.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In mice given 0.5 M NaCl as the only drinking fluid, oxytocin knockout and wild-type mice decreased food intake and body weight and increased fluid ingestion, with no genotypic differences.

    In plain wordsIn mice, animals without oxytocin responded to salt-water dehydration in the same way as normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeFood intake, body weight and fluid ingestion during sustained dehydration
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Additionally, in an experimental model of sustained dehydration previously developed in rats, 0.5 M NaCl was the only available drinking fluid.
    1 context sentence
    Summary · context
    Like rats subjected to this paradigm, OT KO and WT mice decreased food intake, decreased body weight and increased fluid ingestion with no genotypic differences.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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