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Study · Animal study (in vivo) · chicken · 2006

2 results

The melanocortin circuit in obese and lean strains of chicks.

Hen G, Yosefi S, Simchaev V, Shinder D, Hruby VJ, Friedman-Einat M

The Journal of endocrinology1 Aug 2006Cited by 30 (Europe PMC)

PMID16899585 (opens in a new tab)PMCIDPMC2730167 (opens in a new tab)DOI10.1677/joe.1.06783 (opens in a new tab)PepBankPUB-16899585
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In feed-restricted broiler chickens, a single intravenous MT-II injection attenuated food intake on exposure to ad libitum feeding.

    In plain wordsIn broiler chickens, Melanotan II reduced eating when food became freely available.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake on ad libitum refeeding after feed restriction
    Study

    chickenn: not reported in source

    Broiler chickens (obese model)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 mg/kg body weight · intravenous · Single injectionAs given in this study (chicken).

    Source sentences

    Summary
    A single i.v. injection of the synthetic peptide melanotan-II (MT-II; 1 mg/kg body weight) into the wing vein of feed-restricted birds led to attenuation of food intake upon exposure to feeding ad libitum in both broiler and layer chickens.
    1 context sentence
    Summary · context
    In this study, we compared the physiological response to an exogenous MC3/4R agonist and the hypothalamic expression of proopic melanocortin (POMC) gene, encoding few MC3/4R ligands, between broiler and layer chicken strains.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In feed-restricted layer chickens, a single intravenous MT-II injection attenuated food intake on exposure to ad libitum feeding.

    In plain wordsIn layer chickens, Melanotan II reduced eating when food became freely available.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake on ad libitum refeeding after feed restriction
    Study

    chickenn: not reported in source

    Layer chickens (lean model)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 mg/kg body weight · intravenous · Single injectionAs given in this study (chicken).

    Source sentences

    Summary
    A single i.v. injection of the synthetic peptide melanotan-II (MT-II; 1 mg/kg body weight) into the wing vein of feed-restricted birds led to attenuation of food intake upon exposure to feeding ad libitum in both broiler and layer chickens.
    1 context sentence
    Summary · context
    In this study, we compared the physiological response to an exogenous MC3/4R agonist and the hypothalamic expression of proopic melanocortin (POMC) gene, encoding few MC3/4R ligands, between broiler and layer chicken strains.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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