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Study · In vitro (cells) · rat · 2007

2 results

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis.

Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I

Neurobiology of aging21 Jul 2006Cited by 86 (Europe PMC)

PMID16859812 (opens in a new tab)DOI10.1016/j.neurobiolaging.2006.05.036 (opens in a new tab)PepBankPUB-16859812
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured adult rat hippocampal progenitors, Cerebrolysin counteracted FGF-2 effects and induced neuronal lineage.

    In plain wordsIn cells from adult rat brains, Cerebrolysin counteracted FGF-2 effects and promoted neuronal lineage.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal lineage induction
    Study

    ratn: not reported in source

    Cultured adult rat hippocampal progenitors
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as well as an Alzheimer peptidergic drug, Cerebrolysin((R)) (CL), in which we found these neurotrophic activities, counteract the effect of FGF-2 in inducing neuronal lineage (early neurogenesis).
    1 context sentence
    Summary · context
    Here we show that elevated FGF-2 enhances the division and nestin levels of cultured adult rat hippocampal progenitors but impairs neuronal lineage determination and maturation of these cells in culture.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured adult rat hippocampal progenitors, Cerebrolysin did not inhibit cell proliferation.

    In plain wordsIn cells from adult rat brains, Cerebrolysin did not inhibit cell multiplication.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedCell proliferation
    Study

    ratn: not reported in source

    Cultured adult rat hippocampal progenitors
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Whereas CNTF is the most active of the neurotrophic factors studied in promoting neurogenesis, CL, probably because of a combined effect of these factors, induces similar changes but without inhibiting cell proliferation.
    1 context sentence
    Summary · context
    Here we show that elevated FGF-2 enhances the division and nestin levels of cultured adult rat hippocampal progenitors but impairs neuronal lineage determination and maturation of these cells in culture.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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