Recruiting of somatotroph cells after combined somatostatin, GHRH and growth hormone (GH) secretagogue stimulation in a study of pituitary GH reserve in prepuberal female rats.

Jiménez-Reina L, García-Martínez E, Rojas JP, Cañete MD, Bernal G, Cañete R

Histology and histopathology1 Oct 2006

PMID16835832DOI10.14670/hh-21.1103PepBankPUB-16835832

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In prepuberal female rats, GH peaked 15 minutes after combined GHRH and GHRP‑6 administration.
In plain wordsIn rats, GH peaked 15 minutes after combined GHRH and GHRP‑6.
Peptide
GHRP-6
Outcome
Not applicableTiming of peak GH
Study
ratn: not reported in source
Prepuberal female Wistar rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak time
15 minutes
GHRH+GHRP-6
Source sentences
Summary
Peak serum GH values were recorded 15 minutes after administration of GHRH+GHRELIN and GHRH+GHRP-6;
1 context sentence(design, population, supporting numbers)
Summary · context
GH release and changes in the proportion of somatotroph cells were charted in prepuberal female Wistar rats, following administration of several different GH stimuli: GHRH (1 microg/kg), GHRP-6 (1 microg/kg), GHRELIN (1 microg/kg) and combined GHRH-based treatments, with or without SRIH pretreatment…
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1683583201
02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In prepuberal female rats, SRIH pretreatment inhibited GH release and prevented stimulation responses, including GHRH plus GHRP‑6, for at least 30 minutes.
In plain wordsIn rats, somatostatin pretreatment inhibited GH release and responses to combined GHRH and GHRP‑6 for at least 30 minutes.
Peptide
GHRP-6
Outcome
DecreaseGH response after SRIH pretreatment
Study
ratn: not reported in source
Prepuberal female Wistar rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
SRIH pretreatment (- 90 min) inhibited GH release, with a subsequent "escape" and lack of response to stimulation which lasted at least 30 minutes except following administration of GHRH.
1 context sentence(design, population, supporting numbers)
Summary · context
GH release and changes in the proportion of somatotroph cells were charted in prepuberal female Wistar rats, following administration of several different GH stimuli: GHRH (1 microg/kg), GHRP-6 (1 microg/kg), GHRELIN (1 microg/kg) and combined GHRH-based treatments, with or without SRIH pretreatment…
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1683583202

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Version history

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Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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