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Study · Animal study (in vivo) · sprague-dawley rats · 2006

2 results

Effect of daily parathyroid hormone (1-34) on lumbar fusion in a rat model.

Lawrence JP, Ennis F, White AP, Magit D, Polzhofer G, Drespe I, Troiano NW, Grauer JN

The spine journal : official journal of the North American Spine Society1 Jul 2006Cited by 31 (Europe PMC)

PMID16825043 (opens in a new tab)DOI10.1016/j.spinee.2005.10.010 (opens in a new tab)PepBankPUB-16825043
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after lumbar fusion surgery, PTH(1-34) produced a numerically higher fusion rate than placebo.

    In plain wordsIn rats after lumbar fusion surgery, PTH(1-34) produced a numerically higher fusion rate than placebo.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseLumbar fusion rate
    Study

    Sprague-Dawley ratsn = 56

    Posterolateral lumbar fusion with iliac crest autograft
    Comparator
    Placebo/control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · injection · 6 weeksAs given in this study (Sprague-Dawley rats).

    Measurements

    Fusion rate
    52%
    PTH(1-34), 15/29
    Fusion rate
    37%
    control, 10/27

    Source sentences

    Summary
    Manual palpation revealed the control group to have a fusion rate of 37% (10/27) and the PTH(1-34)-treated group to have a fusion rate of 52% (15/29).
    4 context sentences
    Summary · context
    Single-level, intertransverse process spinal fusions were performed with iliac crest autograft in 56 Sprague-Dawley rats.
    Summary · context
    Animals received daily injections of placebo or PTH(1-34).
    Summary · context
    At 6 weeks, fusion masses were assessed by manual palpation.
    Summary · context
    Serum osteocalcin levels were assessed in a subset of the animals.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after lumbar fusion surgery, serum osteocalcin was higher with PTH(1-34) than control.

    In plain wordsIn rats after lumbar fusion surgery, serum osteocalcin was higher with PTH(1-34) than control.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSerum osteocalcin
    Study

    Sprague-Dawley ratsn: not reported in source

    Posterolateral lumbar fusion with iliac crest autograft
    Comparator
    Placebo/control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · injection · 6 weeksAs given in this study (Sprague-Dawley rats).

    Measurements

    Mean serum osteocalcin
    88.6 ng/L
    PTH(1-34)
    Mean serum osteocalcin
    59.8 ng/L
    control

    Source sentences

    Summary
    Mean serum osteocalcin levels were 59.8 and 88.6 ng/L for the control and PTH(1-34) groups, respectively.
    4 context sentences
    Summary · context
    Single-level, intertransverse process spinal fusions were performed with iliac crest autograft in 56 Sprague-Dawley rats.
    Summary · context
    Animals received daily injections of placebo or PTH(1-34).
    Summary · context
    At 6 weeks, fusion masses were assessed by manual palpation.
    Summary · context
    Serum osteocalcin levels were assessed in a subset of the animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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