Vasotocin and mesotocin stimulate the biosynthesis of neurosteroids in the frog brain.

Do-Rego JL, Acharjee S, Seong JY, Galas L, Alexandre D, Bizet P, Burlet A, Kwon HB, Luu-The V, Pelletier G, Vaudry H

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Jun 2006Cited by 35 (Europe PMC)

PMID16793882PMCIDPMC6673836DOI10.1523/jneurosci.4469-05.2006PepBankPUB-16793882

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In frog hypothalamic explants, oxytocin mimicked the stimulatory effect of vasotocin and mesotocin on neurosteroid biosynthesis.
In plain wordsIn lab tests on frog brain tissue, oxytocin raised the production of brain steroids, like vasotocin and mesotocin did.
Peptide
Oxytocin
Outcome
IncreaseNeurosteroid biosynthesis stimulated by oxytocin
Study
frogn: not reported in source
hypothalamic explants
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The stimulatory effect of VT and MT on neurosteroid biosynthesis was mimicked by VP and OT
1 context sentence(design, population, supporting numbers)
Summary · context
Because several neurosteroids also regulate reproduction-related behaviors, we investigated the possible effect of VT and the OT ortholog mesotocin (MT) in the control of neurosteroid production.
Report a problemFND-1679388201

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In frog hypothalamic explants, an oxytocin receptor agonist had no effect on neurosteroid biosynthesis.
In plain wordsIn lab tests on frog brain tissue, a drug that activates oxytocin receptors did not change brain steroid production.
Peptide
Oxytocin
Outcome
No significant changeNeurosteroid biosynthesis with oxytocin receptor agonist
Study
frogn: not reported in source
hypothalamic explants
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
whereas V2 and OT receptor agonists had no effect.
1 context sentence(design, population, supporting numbers)
Summary · context
Because several neurosteroids also regulate reproduction-related behaviors, we investigated the possible effect of VT and the OT ortholog mesotocin (MT) in the control of neurosteroid production.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1679388202
03LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In frog hypothalamic explants, oxytocin receptor antagonists did not affect vasotocin-induced neurosteroid production.
In plain wordsIn lab tests on frog brain tissue, an oxytocin receptor blocker did not change the steroid production caused by vasotocin.
Peptide
Oxytocin
Outcome
No significant changeVasotocin-induced neurosteroid production with oxytocin receptor antagonist
Study
frogn: not reported in source
hypothalamic explants
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
was not affected by V2 and OT receptor antagonists.
1 context sentence(design, population, supporting numbers)
Summary · context
Because several neurosteroids also regulate reproduction-related behaviors, we investigated the possible effect of VT and the OT ortholog mesotocin (MT) in the control of neurosteroid production.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1679388203
04LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In frog hypothalamic explants, the effect of mesotocin on neurosteroidogenesis was markedly attenuated by selective oxytocin and V1a receptor antagonists.
In plain wordsIn lab tests on frog brain tissue, blockers of oxytocin and V1a receptors strongly reduced the steroid production caused by mesotocin.
Peptide
Oxytocin
Outcome
DecreaseMesotocin-induced neurosteroid production with oxytocin receptor antagonist
Study
frogn: not reported in source
hypothalamic explants
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Concurrently, the effect of MT on neurosteroidogenesis was markedly attenuated by selective OT and V1a receptor antagonists but not by a V2 antagonist.
1 context sentence(design, population, supporting numbers)
Summary · context
Because several neurosteroids also regulate reproduction-related behaviors, we investigated the possible effect of VT and the OT ortholog mesotocin (MT) in the control of neurosteroid production.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1679388204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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