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Study · In vitro (cells) · rat · 2006

2 results

Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes.

Zolotarev YA, Dolotov OV, Inozemtseva LS, Dadayan AK, Dorokhova EM, Andreeva LA, Alfeeva LY, Grivennikov IA, Myasoedov NF

Amino acids26 May 2006Cited by 9 (Europe PMC)

PMID16773243 (opens in a new tab)DOI10.1007/s00726-006-0328-8 (opens in a new tab)PepBankPUB-16773243
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Pharmacokinetics

    In rat basal forebrain plasma membranes and glial and neuronal cell cultures, the main processes in Semax degradation were splitting away of ME and GP, and formation of pentapeptides.

    In plain wordsIn lab tests with rat brain cells and membranes, Semax was mainly broken down by loss of ME and GP and formation of pentapeptides.

    Peptide
    Semax
    Outcome
    Not applicablePredominant degradation processes of Semax
    Study

    ratn: not reported in source

    Rat basal forebrain glial and neuronal cell cultures and plasma membranes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The splitting away of ME and GP, and formation of pentapeptides are the predominant processes in the presence of all tested objects
    1 context sentence
    Summary · context
    The method has been applied for the investigation of degradation dynamics of the neuroactive heptapeptide MEHFPGP (Semax) in the presence of plasma membranes, and cultures of glial and neuronal cells obtained from the rat basal forebrain.
  2. 02LabIn vitro (cells)Pharmacokinetics

    The pattern of peptide products formed from Semax differed between glial and neuronal cells from rat basal forebrain.

    In plain wordsIn lab tests, rat brain glial cells and neurons broke Semax down into different sets of fragments.

    Peptide
    Semax
    Outcome
    Not applicableDifference in Semax degradation products between glial and neuronal cells
    Study

    ratn: not reported in source

    Rat basal forebrain glial and neuronal cell cultures and plasma membranes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas the difference in patterns of resulting peptide products for glial and neuronal cells has been detected.
    1 context sentence
    Summary · context
    The method has been applied for the investigation of degradation dynamics of the neuroactive heptapeptide MEHFPGP (Semax) in the presence of plasma membranes, and cultures of glial and neuronal cells obtained from the rat basal forebrain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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