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Study · Measured the body's own peptide · 2006

1 result

Alterations in 5-HT2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein.

Shi J, Damjanoska KJ, Zemaitaitis B, Garcia F, Carrasco G, Sullivan NR, She Y, Young KH, Battaglia G, Van De kar LD, Howland DS, Muma NA

Neuropharmacology1 Sept 2006Cited by 11 (Europe PMC)

PMID16769091 (opens in a new tab)DOI10.1016/j.neuropharm.2006.04.012 (opens in a new tab)PepBankPUB-16769091
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In transgenic rats, RGS-insensitive Galphaq rats had higher oxytocin (and corticosterone) responses to (-)DOI than rats over-expressing wild-type Galphaq.

    In plain wordsIn rats, the body's own oxytocin response to a serotonin-receptor drug was higher in one transgenic strain than in another.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin response to the 5-HT2A/2C agonist (-)DOI
    Study

    ratn: not reported in source

    Comparator
    Gq-Tg rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    RGSi-Tg rats had higher oxytocin and corticosterone responses to (-)DOI, a 5-HT2A/2C receptor agonist, compared to Gq-Tg rats.
    1 context sentence
    Summary · context
    This study investigated the effects of over-expression of wild-type Galphaq proteins (Gq-Tg) and over-expression of RGS-insensitive Galphaq proteins (G188S, RGSi-Tg) on 5-HT2A receptor mediated signaling in transgenic rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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