In ammonia-treated mouse hippocampal slices, GVS-111 did not prevent impaired long-term potentiation maintenance.
In plain wordsIn lab tests with mouse brain slices, GVS-111 did not prevent ammonia-related impairment of long-term potentiation.
- Peptide
- Noopept (omberacetam)
- Outcome
- No significant changeLong-term potentiation maintenance
- Study
mousen: not reported in source
Ammonium chloride-treated hippocampal slices- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Taurine and the mitochondrial enhancer l-carnitine, but not the antioxidants (ascorbate, carnosine, and the novel compound GVS-111) or the osmolyte betaine prevented this impairment.
1 context sentence(design, population, supporting numbers)
We have now studied the protective action of taurine on this paradigm by analyzing LTP characteristics in mouse hippocampal slices treated with ammonium chloride (1 mM) in the presence of taurine (1 mM), an ubiquitous osmolyte, antioxidant, and neuromodulator, as well as other substances with such properties.