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Study · Measured the body's own peptide · 2006

1 result

Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators.

Nilsson M, Sørensen OE, Mörgelin M, Weineisen M, Sjöbring U, Herwald H

Thrombosis and haemostasis1 Jun 2006Cited by 31 (Europe PMC)

PMID16732377 (opens in a new tab)DOI10.1160/th05-08-0572 (opens in a new tab)PepBankPUB-16732377
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Other

    Human neutrophils activated by streptolysin O from S. pyogenes secreted neutrophil-borne proteins, including the body's own LL‑37.

    In plain wordsIn lab tests, human white blood cells exposed to a bacterial toxin released the body's own LL‑37.

    Peptide
    LL-37
    Outcome
    IncreaseLL-37 release from streptolysin O-activated neutrophils
    Study

    humann: not reported in source

    Human polymorphonuclear neutrophils
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    As a consequence, PMNs secrete heparin-binding protein, a potent inducer of vascular leakage, and neutrophil-borne proteins, including LL-37, alpha-defensins, and elastase.
    1 context sentence
    Summary · context
    Here we report that streptolysin O (SLO), a cytolytic exotoxin secreted by S. pyogenes, activates human polymorphonuclear neutrophils (PMNs) by perforating these cells.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:00 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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