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Study · In vitro (cells) · 2006

5 results

Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the arc.

Mano-Otagiri A, Nemoto T, Sekino A, Yamauchi N, Shuto Y, Sugihara H, Oikawa S, Shibasaki T

Endocrinology25 May 2006Cited by 38 (Europe PMC)

PMID16728494 (opens in a new tab)DOI10.1210/en.2005-1619 (opens in a new tab)PepBankPUB-16728494
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured hypothalamic neurons, KP-102 increased NPY mRNA expression.

    In plain wordsIn cultured brain neurons, KP-102 raised the level of NPY messenger RNA.

    Peptide
    GHRP-2
    Outcome
    IncreaseNPY mRNA expression in cultured hypothalamic neurons
    Study

    n: not reported in source

    Cultured hypothalamic neurons
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Competitive RT-PCR analysis of GHRH mRNA expression in the cultured hypothalamic neurons showed that KP-102 increased NPY mRNA expression level and that NPY decreased GHRH mRNA expression level.
    1 context sentence
    Summary · context
    To clarify how GHS-R affects GHRH expression in the Arc, we compared the numbers of GHS-R-positive, GHRH, and NPY neurons between Tg and wild-type rats.
  2. 02LabIn vitro (cells)Mechanism

    In cultured hypothalamic neurons, KP-102 increased GHRH mRNA expression when anti-NPY IgG was present.

    In plain wordsIn cultured brain neurons, KP-102 raised GHRH messenger RNA when NPY was blocked.

    Peptide
    GHRP-2
    Outcome
    IncreaseGHRH mRNA expression in the presence of anti-NPY IgG
    Study

    n: not reported in source

    Cultured hypothalamic neurons
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-102 increased GHRH mRNA expression level in the presence of anti-NPY IgG.
    1 context sentence
    Summary · context
    To clarify how GHS-R affects GHRH expression in the Arc, we compared the numbers of GHS-R-positive, GHRH, and NPY neurons between Tg and wild-type rats.
  3. 03LabIn vitro (cells)Mechanism

    In cultured hypothalamic neurons, KP-102 had no significant effect on somatostatin mRNA expression.

    In plain wordsIn cultured brain neurons, KP-102 did not significantly change somatostatin messenger RNA.

    Peptide
    GHRP-2
    Outcome
    No significant changeSomatostatin mRNA expression in cultured hypothalamic neurons
    Study

    n: not reported in source

    Cultured hypothalamic neurons
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-102 showed no significant effect on somatostatin mRNA expression.
    1 context sentence
    Summary · context
    To clarify how GHS-R affects GHRH expression in the Arc, we compared the numbers of GHS-R-positive, GHRH, and NPY neurons between Tg and wild-type rats.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Mechanism

    In rats with reduced GHS-R expression, the number of Fos-positive neurons in response to KP-102 was lower than in wild-type rats.

    In plain wordsIn rats with less ghrelin receptor, fewer brain neurons switched on after KP-102 than in normal rats.

    Peptide
    GHRP-2
    Outcome
    DecreaseFos-positive neurons in response to KP-102 in transgenic rats
    Study

    ratn: not reported in source

    Transgenic rats with reduced GHS-R expression in the arcuate nucleus
    Comparator
    Wild-type rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The numbers of Fos-positive neurons and Fos-positive GHRH neurons in response to KP-102 were decreased in Tg rats.
    1 context sentence
    Summary · context
    To clarify how GHS-R affects GHRH expression in the Arc, we compared the numbers of GHS-R-positive, GHRH, and NPY neurons between Tg and wild-type rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Mechanism

    In rats with reduced GHS-R expression, the number of Fos-positive GHRH neurons in response to KP-102 was lower than in wild-type rats.

    In plain wordsIn rats with less ghrelin receptor, fewer GHRH neurons switched on after KP-102 than in normal rats.

    Peptide
    GHRP-2
    Outcome
    DecreaseFos-positive GHRH neurons in response to KP-102 in transgenic rats
    Study

    ratn: not reported in source

    Transgenic rats with reduced GHS-R expression in the arcuate nucleus
    Comparator
    Wild-type rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The numbers of Fos-positive neurons and Fos-positive GHRH neurons in response to KP-102 were decreased in Tg rats.
    1 context sentence
    Summary · context
    To clarify how GHS-R affects GHRH expression in the Arc, we compared the numbers of GHS-R-positive, GHRH, and NPY neurons between Tg and wild-type rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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