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Study · Not a test of the peptide alone · 2006

3 results

Effect of obesity and morbid obesity on the growth hormone (GH) secretion elicited by the combined GHRH + GHRP-6 test.

Kelestimur F, Popovic V, Leal A, Van Dam PS, Torres E, Perez Mendez LF, Greenman Y, Koppeschaar HP, Dieguez C, Casanueva FF

Clinical endocrinology1 Jun 2006Cited by 30 (Europe PMC)

PMID16712669 (opens in a new tab)DOI10.1111/j.1365-2265.2006.02525.x (opens in a new tab)PepBankPUB-16712669
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    In subjects with normal pituitary function, adiposity was negatively associated with the GH peak after combined GHRH and GHRP‑6.

    In plain wordsGreater body fat was linked to a lower GH peak after the combined GHRH and GHRP‑6 test.

    Peptide
    GHRP-6
    Outcome
    DecreaseAdiposity association with GH peak
    Study

    n = 366

    GHRH + GHRP-6 diagnostic test
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Correlation
    −0.503 r
    Adiposity and GH peak

    Source sentences

    Summary
    A regression analysis of the 366 subjects with normal pituitary function indicated that adiposity had a negative effect on the elicited GH peak (r = -0.503, P < 0.0001).
    1 context sentence
    Summary · context
    In this work, the role of obesity in the GH response elicited by the GHRH + GHRP-6 test was assessed in a large population of obese and nonobese subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    In subjects with BMI up to 35, the combined GHRH and GHRP‑6 test retained the accepted normal and deficient GH thresholds.

    In plain wordsThe combined GHRH and GHRP‑6 test retained its accepted GH thresholds in subjects with BMI up to 35.

    Peptide
    GHRP-6
    Outcome
    Not applicableGH thresholds at BMI up to 35
    Study

    n: not reported in source

    GHRH + GHRP-6 diagnostic test
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Normal GH peak
    ≥ 20 microg/l
    BMI <=35
    GH deficiency peak
    ≤ 10 microg/l
    BMI <=35

    Source sentences

    Summary
    A receiver operating characteristic (ROC) curve analysis showed that in subjects with a BMI or =20 microg/l: normal secretion; GH peaks < or =10 microg/l: GH deficiency), were fully operative.
    1 context sentence
    Summary · context
    In this work, the role of obesity in the GH response elicited by the GHRH + GHRP-6 test was assessed in a large population of obese and nonobese subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    In subjects with BMI above 35, combined GHRH and GHRP‑6 testing indicated normality at lower GH peaks than standard thresholds.

    In plain wordsSubjects with BMI above 35 required lower GH thresholds for the combined GHRH and GHRP‑6 test.

    Peptide
    GHRP-6
    Outcome
    Not applicableGH thresholds at BMI above 35
    Study

    n: not reported in source

    GHRH + GHRP-6 diagnostic test
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Normal GH peak
    ≥ 15 microg/l
    BMI >35
    GH deficiency peak
    ≤ 5 microg/l
    BMI >35

    Source sentences

    Summary
    However, in subjects with a BMI > 35, normality was indicated by GH peaks > or =15 microg/l and GH deficiency by peaks < or =5 microg/l (1 microg/l = 2.6 mU/l).
    1 context sentence
    Summary · context
    In this work, the role of obesity in the GH response elicited by the GHRH + GHRP-6 test was assessed in a large population of obese and nonobese subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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