Anti-aging peptide bioregulators induce reactivation of chromatin.

Lezhava T, Monaselidze J, Kadotani T, Dvalishvili N, Buadze T

Georgian medical news1 Apr 2006Cited by 1 (Europe PMC)

PMID16705247PepBankPUB-16705247

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In cultured lymphocytes from old people, epitalon activated synthetic processes by reactivating ribosomal genes through decondensation of nucleolus organizer regions.
In plain wordsIn lab-grown blood cells from older donors, epitalon switched on ribosomal genes by loosening their packed DNA.
Peptide
Epitalon
Outcome
IncreaseRibosomal gene reactivation (NOR deheterochromatinization)
Study
humann: not reported in source
cultivated lymphocytes from old people (75-88 yr.)
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
activate synthetic processes, caused by reactivation of ribosomal genes as a result of deheterochromatinization (decondensation) of nucleolus organizer regions
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524701
02LabEx vivo tissueMechanism
In cultured lymphocytes from old people, epitalon unrolled (deheterochromatinized) total heterochromatin.
In plain wordsIn lab-grown blood cells from older donors, epitalon loosened tightly packed DNA overall.
Peptide
Epitalon
Outcome
DecreaseTotal heterochromatin condensation
Study
humann: not reported in source
cultivated lymphocytes from old people (75-88 yr.)
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
induce unrolling (deheterochromatinization) of total heterochromatin
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524702
03LabEx vivo tissueMechanism
In cultured lymphocytes from old people, epitalon released genes repressed by heterochromatinization of euchromatic regions.
In plain wordsIn lab-grown blood cells from older donors, epitalon released genes that were switched off by tight DNA packing.
Peptide
Epitalon
Outcome
DecreaseFacultative heterochromatin in euchromatic regions
Study
humann: not reported in source
cultivated lymphocytes from old people (75-88 yr.)
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
release genes repressed by heterochromatinization (condensation) of euchromatic regions forming facultative heterochromatin
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524703
04LabEx vivo tissueMechanism
In cultured lymphocytes from old people, epitalon induced deheterochromatinization of pericentromeric structural heterochromatin of chromosomes 1 and 9.
In plain wordsIn lab-grown blood cells from older donors, epitalon loosened packed DNA near the centre of chromosomes 1 and 9.
Peptide
Epitalon
Outcome
DecreasePericentromeric structural heterochromatin of chromosomes 1 and 9
Study
humann: not reported in source
cultivated lymphocytes from old people (75-88 yr.)
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
epitalon and livagen induce deheterochromatinization (decondensation) of pericentromeric structural heterochromatin of the chromosomes1 and 9
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524704
05LabIn vitro (cells)Mechanism
In lymphocytes from old people, Livagen induced pericentromeric structural heterochromatin decondensation in chromosome 1.
In plain wordsIn cells from old donors, Livagen induced pericentromeric heterochromatin decondensation in chromosome 1.
Peptide
Livagen (KEDA)
Outcome
IncreaseChromosome 1 pericentromeric heterochromatin decondensation
Study
humann: not reported in source
Cultivated lymphocytes from old people
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
epitalon and livagen induce deheterochromatinization (decondensation) of pericentromeric structural heterochromatin of the chromosomes1 and 9.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524705
06LabIn vitro (cells)Mechanism
In lymphocytes from old people, Livagen induced pericentromeric structural heterochromatin decondensation in chromosome 9.
In plain wordsIn cells from old donors, Livagen induced pericentromeric heterochromatin decondensation in chromosome 9.
Peptide
Livagen (KEDA)
Outcome
IncreaseChromosome 9 pericentromeric heterochromatin decondensation
Study
humann: not reported in source
Cultivated lymphocytes from old people
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
epitalon and livagen induce deheterochromatinization (decondensation) of pericentromeric structural heterochromatin of the chromosomes1 and 9.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524706
07LabIn vitro (cells)Mechanism
In cultured lymphocytes from older people, Vilon did not induce pericentromeric structural heterochromatin decondensation.
In plain wordsIn lab tests with lymphocytes, Vilon did not unfold structural chromatin near chromosome centers.
Peptide
Vilon (KE)
Outcome
No significant changePericentromeric structural heterochromatin decondensation
Study
humann: not reported in source
Cultured lymphocytes from older people
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
However, vilon does not induce deheterochromatinization of pericentromeric structural heterochromatin.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people.
Report a problemFND-1670524707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 5 to 11Current
28 Oct 2026, 02:02 UTC
The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.
Study results updated
Versions 3 to 4
21 Oct 2026, 16:35 UTC
The same notice was added 2 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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