In mice, oxytocin gene deletion significantly increased saccharin solution intake in the dark and light photoperiods compared with wild type, and the result was replicated.
In plain wordsIn mice that lack the oxytocin gene, intake of a sweetener solution was higher than in normal mice, day and night.
- Peptide
- Oxytocin
- Outcome
- IncreaseSaccharin solution intake in oxytocin knockout mice
- Study
mousen: not reported in source
oxytocin knockout mice versus wild type- Comparator
- Wild-type mice
- Outcome group
- Appetite and food intake · Metabolic and weight
Source sentences
Compared to WT mice, OT KO mice consumed significantly greater volumes of saccharin solution during the dark and light photoperiods on the first day and subsequent days of the study. The results were replicated when the experiment was repeated in the same animals.
1 context sentence(design, population, supporting numbers)
In this study we examined the ingestion of a non-nutritive sweetener, 0.2% saccharin in sucrose-experienced OT KO and WT mice given a two-bottle choice between saccharin solution and water available ad libitum for 4 days.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.