Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats.

Hrncić D, Stanojlović O, Zivanović D, Susić V

Pharmacology26 Apr 2006Cited by 4 (Europe PMC)

PMID16645330DOI10.1159/000093001PepBankPUB-16645330

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP alone had no significant effect on seizure latency.
In plain wordsIn rats with induced seizures, DSIP alone did not change the time to a seizure.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeLatency to seizure with DSIP alone
Study
ratn: not reported in source
Wistar rats, metaphit audiogenic seizure model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1.0 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP or VPA alone expressed no significant effect on the latency duration
1 context sentence(design, population, supporting numbers)
Summary · context
Metaphit-treated rats displaying seizures in 8 previous tests were i.p. injected with VPA (50 mg/kg) or DSIP (1.0 mg/kg) or their combination.
Report a problemFND-1664533001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced seizures, adding DSIP to a nonprotective valproate dose significantly prolonged latency to seizure during 6 h after injection, while valproate alone had no significant effect.
In plain wordsIn rats with induced seizures, DSIP added to valproate delayed seizures, while valproate alone did not.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseLatency to seizure with DSIP added to valproate
Study
ratn: not reported in source
Wistar rats, metaphit audiogenic seizure model
Comparator
Valproate alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1.0 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
but their combination significantly prolonged latency to seizure during 6 h after injection
2 context sentences(design, population, supporting numbers)
Summary · context
The results show that DSIP potentiated anticonvulsive effects of a nonprotective VPA dose in a metaphit model of audiogenic seizures without influencing its neurotoxicity.
Summary · context
Metaphit-treated rats displaying seizures in 8 previous tests were i.p. injected with VPA (50 mg/kg) or DSIP (1.0 mg/kg) or their combination.
Report a problemFND-1664533002
03AnimalAnimal study (in vivo)Safety outcome
In rats, DSIP added to valproate caused no significant motor impairment and did not influence valproate neurotoxicity.
In plain wordsIn rats, adding DSIP to valproate did not cause extra movement problems.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeMotor impairment (chimney test) with DSIP added to valproate
Study
ratn: not reported in source
Wistar rats, metaphit audiogenic seizure model
Comparator
Valproate alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1.0 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
while inducing no significant motor impairment.
2 context sentences(design, population, supporting numbers)
Summary · context
without influencing its neurotoxicity.
Summary · context
Metaphit-treated rats displaying seizures in 8 previous tests were i.p. injected with VPA (50 mg/kg) or DSIP (1.0 mg/kg) or their combination.
Report a problemFND-1664533003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced seizures, DSIP, valproate and their combination did not abolish EEG epileptiform activity.
In plain wordsIn rats with induced seizures, DSIP, valproate and the two together did not remove seizure signs on the brain recording.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeEEG epileptiform activity with DSIP, valproate and their combination
Study
ratn: not reported in source
Wistar rats, metaphit audiogenic seizure model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1.0 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Neither the applied drugs nor their combination abolished metaphit-provoked EEG epileptiform activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Metaphit-treated rats displaying seizures in 8 previous tests were i.p. injected with VPA (50 mg/kg) or DSIP (1.0 mg/kg) or their combination.
Report a problemFND-1664533004

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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