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Study · In vitro (cells) · 2006

9 results

Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines.

Fan YZ, Chang H, Yu Y, Liu J, Wang R

Peptides27 Apr 2006Cited by 21 (Europe PMC)

PMID16644063 (opens in a new tab)DOI10.1016/j.peptides.2006.03.012 (opens in a new tab)PepBankPUB-16644063
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human leukemia cell lines, thymosin alpha‑1 significantly depressed proliferation after 96 h of treatment.

    In plain wordsIn human leukemia cells in the lab, thymosin alpha‑1 slowed cell growth after 96 hours.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProliferation of leukemia cells
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · 96 hAs given in this study (human).

    Source sentences

    Summary
    The proliferation was significantly depressed after 96 h of treatment with Talpha1
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  2. 02LabIn vitro (cells)Activity measurement

    In human leukemia cell lines, thymosin alpha‑1 led to obvious signs of apoptosis (cell morphology, nuclei condensation and Annexin V binding).

    In plain wordsIn human leukemia cells in the lab, thymosin alpha‑1 led to signs of programmed cell death.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseApoptosis of leukemia cells
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    obvious signs of apoptosis, i.e., cell morphology, nuclei condensation and Annexin V binding, were observed thereafter.
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  3. 03LabIn vitro (cells)Mechanism

    In apoptotic human leukemia cells, thymosin alpha‑1 treatment was accompanied by up-regulation of Fas/Apo1 (CD95).

    In plain wordsIn human leukemia cells in the lab, thymosin alpha‑1 raised levels of the death receptor Fas.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseFas/Apo1 (CD95) expression
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the up-regulation of Fas/Apol (CD95) and decrease in bcl-2 anti-apoptotic gene expression were observed in apoptotic cells
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  4. 04LabIn vitro (cells)Mechanism

    In apoptotic human leukemia cells, thymosin alpha‑1 treatment was accompanied by decreased bcl-2 anti-apoptotic gene expression.

    In plain wordsIn human leukemia cells in the lab, thymosin alpha‑1 lowered activity of the anti-death gene bcl-2.

    Peptide
    Thymosin alpha-1
    Outcome
    Decreasebcl-2 anti-apoptotic gene expression
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decrease in bcl-2 anti-apoptotic gene expression were observed in apoptotic cells
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  5. 05LabIn vitro (cells)Mechanism

    In human leukemia cell lines, thymosin alpha‑1 slightly inhibited the expression and function of P-glycoprotein.

    In plain wordsIn human leukemia cells in the lab, thymosin alpha‑1 slightly reduced the drug-pump protein P-glycoprotein and its function.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseP-glycoprotein expression and function
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression and the function of P-glycoprotein (P-gp) can be slightly inhibited by Talpha1.
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  6. 06LabIn vitro (cells)Activity measurement

    K562 and K562/ADM leukemia cells were more sensitive to thymosin alpha‑1 than HL-60 cells.

    In plain wordsIn the lab, two leukemia cell lines (K562, K562/ADM) responded more strongly to thymosin alpha‑1 than the HL-60 line.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedSensitivity of K562 and K562/ADM versus HL-60 cells
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Comparator
    HL-60 cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is noteworthy that K562 and K562/ADM were more sensitive than HL-60 cells when subjected to Talpha1.
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  7. 07LabIn vitro (cells)Activity measurement

    HepG-2 human hepatoma cells were significantly less sensitive to thymosin alpha‑1 than all the human leukemia cell lines.

    In plain wordsIn the lab, a human liver cancer cell line responded much less to thymosin alpha‑1 than the leukemia cell lines.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedSensitivity of HepG-2 hepatoma cells versus leukemia cells
    Study

    humann: not reported in source

    HepG-2 hepatoma cell line and leukemia cell lines
    Comparator
    Human leukemia cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HepG-2, the human hepatoma cell line, displayed significant less sensitivity to Talpha1 than all the human leukemia cell lines.
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  8. 08LabIn vitro (cells)Mechanism

    The nicotinic receptor antagonist D-tubocurarine significantly antagonized the inhibitory effects of thymosin alpha‑1 on leukemia cells.

    In plain wordsIn the lab, a nicotinic receptor blocker reduced the growth-slowing effect of thymosin alpha‑1 on leukemia cells.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableEffect of D-tubocurarine on thymosin alpha-1 inhibition
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Comparator
    Thymosin alpha-1 without antagonist
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    D-Tubocurarine (TUB), a nicotinic acetylcholine receptors (nAChRs) antagonist, significantly antagonized the inhibition effects induced by Talpha1
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.
  9. 09LabIn vitro (cells)Mechanism

    The muscarinic receptor antagonist atropine did not antagonize the inhibitory effects of thymosin alpha‑1 on leukemia cells.

    In plain wordsIn the lab, a muscarinic receptor blocker did not reduce the effect of thymosin alpha‑1 on leukemia cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeEffect of atropine on thymosin alpha-1 inhibition
    Study

    humann: not reported in source

    Human leukemia cell lines (HL-60, K562, K562/ADM)
    Comparator
    Thymosin alpha-1 without antagonist
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas atropine, a muscarinic acetylcholine receptor antagonist, did not exhibit such effects.
    1 context sentence
    Summary · context
    In the present investigation, the effects of Talpha1 on the proliferation and apoptosis of human leukemia cell lines (HL-60, K562 and K562/ADM) were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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