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Study · Animal study (in vivo) · rat · 2006

6 results

LL-37 protects rats against lethal sepsis caused by gram-negative bacteria.

Cirioni O, Giacometti A, Ghiselli R, Bergnach C, Orlando F, Silvestri C, Mocchegiani F, Licci A, Skerlavaj B, Rocchi M, Saba V, Zanetti M, Scalise G

Antimicrobial agents and chemotherapy1 May 2006Cited by 120 (Europe PMC)

PMID16641434 (opens in a new tab)PMCIDPMC1472226 (opens in a new tab)DOI10.1128/aac.50.5.1672-1679.2006 (opens in a new tab)PepBankPUB-16641434
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In three rat models of gram-negative sepsis, intravenous LL‑37 reduced lethality compared with saline controls.

    In plain wordsIn rats with sepsis, LL‑37 given into a vein lowered deaths compared with saline.

    Peptide
    LL-37
    Outcome
    DecreaseLethality
    Study

    ratn: not reported in source

    Rat models of gram-negative sepsis (LPS, E. coli, cecal ligation and puncture)
    Comparator
    Isotonic sodium chloride solution
    Outcome group
    Mortality · Infection
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    All compounds reduced lethality compared to levels in controls.
    2 context sentences
    Summary · context
    Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 x 10(10) CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture.
    Summary · context
    For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg polymyxin B, 20-mg/kg imipenem, or 60-mg/kg piperacillin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rat models of gram-negative sepsis, LL‑37 significantly reduced bacterial growth compared with saline treatment.

    In plain wordsIn rats with sepsis, LL‑37 reduced bacterial growth more than saline did.

    Peptide
    LL-37
    Outcome
    DecreaseBacterial growth in blood and organs
    Study

    ratn: not reported in source

    Rat models of gram-negative sepsis (LPS, E. coli, cecal ligation and puncture)
    Comparator
    Isotonic sodium chloride solution
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    All drugs tested significantly reduced bacterial growth compared to saline treatment.
    2 context sentences
    Summary · context
    Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 x 10(10) CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture.
    Summary · context
    For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg polymyxin B, 20-mg/kg imipenem, or 60-mg/kg piperacillin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rat models of gram-negative sepsis, plasma endotoxin was significantly lower with LL‑37 than with conventional antibiotics.

    In plain wordsIn rats with sepsis, LL‑37 led to lower blood endotoxin than conventional antibiotics did.

    Peptide
    LL-37
    Outcome
    DecreasePlasma endotoxin concentration
    Study

    ratn: not reported in source

    Rat models of gram-negative sepsis (LPS, E. coli, cecal ligation and puncture)
    Comparator
    Conventional antibiotics
    Outcome group
    Inflammation markers · Infection
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Endotoxin and TNF-alpha plasma levels were significantly higher in conventional antibiotic-treated rats than in LL-37- and polymyxin B-treated animals.
    2 context sentences
    Summary · context
    Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 x 10(10) CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture.
    Summary · context
    For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg polymyxin B, 20-mg/kg imipenem, or 60-mg/kg piperacillin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rat models of gram-negative sepsis, plasma TNF-alpha was significantly lower with LL‑37 than with conventional antibiotics.

    In plain wordsIn rats with sepsis, LL‑37 led to lower blood TNF-alpha than conventional antibiotics did.

    Peptide
    LL-37
    Outcome
    DecreasePlasma TNF-alpha concentration
    Study

    ratn: not reported in source

    Rat models of gram-negative sepsis (LPS, E. coli, cecal ligation and puncture)
    Comparator
    Conventional antibiotics
    Outcome group
    Inflammation markers · Infection
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Endotoxin and TNF-alpha plasma levels were significantly higher in conventional antibiotic-treated rats than in LL-37- and polymyxin B-treated animals.
    2 context sentences
    Summary · context
    Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 x 10(10) CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture.
    Summary · context
    For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg polymyxin B, 20-mg/kg imipenem, or 60-mg/kg piperacillin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rat models of gram-negative sepsis, antimicrobial activity of LL‑37 did not differ significantly from that of polymyxin B.

    In plain wordsIn rats with sepsis, LL‑37 and polymyxin B killed bacteria about equally well.

    Peptide
    LL-37
    Outcome
    No significant changeAntimicrobial activity versus polymyxin B
    Study

    ratn: not reported in source

    Rat models of gram-negative sepsis (LPS, E. coli, cecal ligation and puncture)
    Comparator
    Polymyxin B 1 mg/kg
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    No statistically significant differences between LL-37 and polymyxin B were noted for antimicrobial and antiendotoxin activities.
    2 context sentences
    Summary · context
    Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 x 10(10) CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture.
    Summary · context
    For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg polymyxin B, 20-mg/kg imipenem, or 60-mg/kg piperacillin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rat models of gram-negative sepsis, antiendotoxin activity of LL‑37 did not differ significantly from that of polymyxin B.

    In plain wordsIn rats with sepsis, LL‑37 and polymyxin B neutralised endotoxin about equally well.

    Peptide
    LL-37
    Outcome
    No significant changeAntiendotoxin activity versus polymyxin B
    Study

    ratn: not reported in source

    Rat models of gram-negative sepsis (LPS, E. coli, cecal ligation and puncture)
    Comparator
    Polymyxin B 1 mg/kg
    Outcome group
    Inflammation markers · Infection
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    No statistically significant differences between LL-37 and polymyxin B were noted for antimicrobial and antiendotoxin activities.
    2 context sentences
    Summary · context
    Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 x 10(10) CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture.
    Summary · context
    For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg polymyxin B, 20-mg/kg imipenem, or 60-mg/kg piperacillin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:59 UTC

    First added · source update from Europe PMC

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