Skip to content

Study · Ex vivo tissue · 2006

3 results

[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].

Zolotarev IuA, Dadaian AK, Dolotov OV, Kozik VS, Kost NV, Sokolov OIu, Dorokhova EM, Meshavkin VK, Inozemtseva LS, Gabaeva MV, Andreeva LA, Alfeeva LIu and 10 more

Show all authors

Pavlov TS, Badmaeva KE, Badmaeva SE, Bakaeva ZV, Kopylova GN, Samonina GE, Vas'kovskiĭ BV, Grivennikov IA, Zozulia AA, Miasoedov NF

Bioorganicheskaia khimiia1 Mar 2006Cited by 9 (Europe PMC)

PMID16637290 (opens in a new tab)PepBankPUB-16637290
Publisher pageAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    In blood plasma, the main breakdown products of Selank were the pentapeptide TKPRP, the tripeptide TKP and the dipeptides RP and GP.

    In plain wordsIn lab tests, Selank in blood plasma broke down mainly into smaller peptide pieces named TKPRP, TKP, RP and GP.

    Peptide
    Selank
    Outcome
    Not applicableSelank biodegradation products in blood plasma
    Study

    n: not reported in source

    blood plasma
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the pentapeptide TKPRP, tripeptide TKP, and dipeptides RP and GP were shown to be the major products of Selank biodegradation.
    1 context sentence
    Summary · context
    This approach was used for studying the pathways of biodegradation of the heptapeptide TKPRPGP (Selank) and the tripeptide PGP in blood plasma.
  2. 02LabEx vivo tissueMechanism

    Semax strongly inhibited enkephalin-degrading enzymes in blood plasma, through its action on aminopeptidases.

    In plain wordsIn lab tests, Semax strongly blocked enzymes in blood plasma that break down enkephalins.

    Peptide
    Semax
    Outcome
    DecreaseSemax effect on enkephalinase activity of blood plasma
    Study

    n: not reported in source

    blood plasma
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A high inhibitory effect of Semax on blood plasma enkephalinases was shown to arise from its action on aminopeptidases.
    1 context sentence
    Summary · context
    The enkephalinase activity of blood plasma was studied with the use of evenly tritium-labeled [Leu]enkephalin.
  3. 03LabIn vitro (cells)Pharmacokinetics

    In the presence of nerve cells, the main breakdown products of Semax were the pentapeptide HFPGP and the tripeptide PGP.

    In plain wordsIn cells, Semax broke down mainly into two smaller peptide pieces named HFPGP and PGP.

    Peptide
    Semax
    Outcome
    Not applicableSemax biodegradation products with nerve cells
    Study

    n: not reported in source

    nerve cells
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The study of the biodegradation of the heptapeptide MEHFPGP (Semax) in the presence of nerve cells showed that the major products of its biodegradation are the pentapeptide HFPGP and tripeptide PGP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.