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Study · In vitro (cells) · 2006

2 results

[Interaction of delta sleep-inducing peptide and its analogues with cellular membranes: a structure-function analysis].

Mikhaleva II, Rikhireva GT, Prudchenko IA, Golubev IN

Bioorganicheskaia khimiia1 Mar 2006Cited by 1 (Europe PMC)

PMID16637289 (opens in a new tab)DOI10.1134/s1068162006020087 (opens in a new tab)PepBankPUB-16637289
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In thrombocyte plasma membranes, DSIP disordered lipids, and biologically active analogues caused a statistically reliable disordering similar to the effect of DSIP.

    In plain wordsIn lab tests on platelet membranes, DSIP disturbed the order of membrane lipids.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLipid disordering in thrombocyte plasma membranes
    Study

    n: not reported in source

    Thrombocyte plasma membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The peptides exhibiting biological activity in vivo were shown to cause a statistically reliable disordering of lipids in thrombocyte plasma membranes similar to the effect of DSIP.
    1 context sentence
    Summary · context
    The possibility of a correlation between the membrane properties of the delta sleep-inducing peptide (DSIP) and its analogues and their biological activity in vivo was examined by a comparative study of the membrane effects of these peptides.
  2. 02LabIn vitro (cells)Mechanism

    In thrombocyte plasma membranes, natural DSIP showed a bimodal dose dependence of its membrane effect.

    In plain wordsIn lab tests on platelet membranes, the membrane effect of DSIP followed a two-phase dose pattern.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedDose dependence of the membrane effect
    Study

    n: not reported in source

    Thrombocyte plasma membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The membrane effect of the D-Val2, D-Tyr2, and Tyr1, Pro2 analogues of DSIP had the same bimodal dose dependence characteristic of natural DSIP.
    1 context sentence
    Summary · context
    The possibility of a correlation between the membrane properties of the delta sleep-inducing peptide (DSIP) and its analogues and their biological activity in vivo was examined by a comparative study of the membrane effects of these peptides.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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