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Study · Animal study (in vivo) · mouse · 2006

3 results

Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.

Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I

In vivo (Athens, Greece)1 Mar 2006Cited by 4 (Europe PMC)

PMID16634527 (opens in a new tab)PepBankPUB-16634527
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In female C3H/He mice, long-term low-dose Epitalon showed no toxic effect.

    In plain wordsIn mice, long-term treatment with a small dose of Epitalon showed no toxic effect.

    Peptide
    Epitalon
    Outcome
    No significant changeToxicity of long-term low-dose treatment
    Study

    mousen: not reported in source

    One-year-old female C3H/He mice
    Comparator
    Control mice
    Outcome group
    Adverse events · Whole body
    Studied dose
    0.1 microg, 5 times a weekAs given in this study (mouse).

    Source sentences

    Summary
    Long-term exposure to Epitalon in small doses did not show any toxic effect.
    1 context sentence
    Summary · context
    One-year-old female C3H/He mice were kept for 6.5 months under standard conditions.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female C3H/He mice, Epitalon decreased the number of tumor-bearing mice with malignant tumors.

    In plain wordsIn mice, Epitalon reduced the number of mice that carried malignant tumors.

    Peptide
    Epitalon
    Outcome
    DecreaseMice with malignant tumors
    Study

    mousen: not reported in source

    One-year-old female C3H/He mice
    Comparator
    Control mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1 microg, 5 times a weekAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with Epitalon decreased the number of tumor-bearing mice with malignant tumors
    1 context sentence
    Summary · context
    One-year-old female C3H/He mice were kept for 6.5 months under standard conditions.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female C3H/He mice, Epitalon prevented the development of metastases; none were found in treated mice, while 3 of 9 tumor-bearing control mice had metastases.

    In plain wordsIn mice, Epitalon prevented the spread of tumors: no metastases were found in treated mice, but 3 of 9 tumor-bearing control mice had them.

    Peptide
    Epitalon
    Outcome
    DecreaseMetastases
    Study

    mousen: not reported in source

    One-year-old female C3H/He mice
    Comparator
    Control mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1 microg, 5 times a weekAs given in this study (mouse).

    Source sentences

    Summary
    In control mice, metastases were found in 3 out of 9 tumor-bearing mice, all of them being from tumors of the reproductive organs. Treatment with Epitalon slowed down the development of metastases from spontaneous tumors, and no metastases were found in the experimental mice.
    1 context sentence
    Summary · context
    One-year-old female C3H/He mice were kept for 6.5 months under standard conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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