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Study · Not a test of the peptide alone · 2006

3 results

[Study of the relationship between analgesic activity and structure of synthetic melanocortin analogs].

Ivanova DM, Vilenskiĭ DA, Levitskaia NG, Andreeva LA, Alfeeva LIu, Kamenskiĭ AA, Miasoedov NF

Izvestiia Akademii nauk. Seriia biologicheskaia1 Mar 2006

PMID16634438 (opens in a new tab)DOI10.1134/s1062359006020105 (opens in a new tab)PepBankPUB-16634438
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 01AnimalNot a test of Semax aloneAnimal study (in vivo)Activity measurement

    In rats, truncating N-terminal residues of Semax analogs eliminated analgesic activity in the paw-withdrawal test.

    In plain wordsIn rats, shortened versions of Semax at the start of the chain lost their pain-relieving effect.

    Peptide
    Semax
    Outcome
    DecreaseAnalgesic activity of N-terminal truncated Semax analogs
    Study

    ratn: not reported in source

    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Truncations of the N-terminal residues eliminated the analgesic activity.
    2 context sentences
    Summary · context
    The peptides were administered intraperitoneally at doses of 0.015, 0.05 and 0.5 mg/kg.
    Summary · context
    Rat pain sensitivity was assessed using the paw-withdrawal test.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  2. 02AnimalNot a test of Semax aloneAnimal study (in vivo)Activity measurement

    In rats, Semax analogs with lysine in place of N-terminal methionine, or with glucuronic acid attached to methionine, showed an analgesic effect.

    In plain wordsIn rats, Semax analogs with a swapped or modified first amino acid still reduced pain sensitivity.

    Peptide
    Semax
    Outcome
    DecreaseAnalgesic activity of lysine-substituted and glucuronyl Semax analogs
    Study

    ratn: not reported in source

    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    The peptide analgesic effect was observed after the replacement of the N-terminal methionine with lysine or after the attachment of glucuronic acid to the methionine
    2 context sentences
    Summary · context
    The peptides were administered intraperitoneally at doses of 0.015, 0.05 and 0.5 mg/kg.
    Summary · context
    Rat pain sensitivity was assessed using the paw-withdrawal test.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  3. 03AnimalNot a test of Semax aloneAnimal study (in vivo)Activity measurement

    In rats, the Semax analog with glycine instead of methionine had no effect on pain sensitivity.

    In plain wordsIn rats, the Semax analog with glycine in place of methionine did not change pain sensitivity.

    Peptide
    Semax
    Outcome
    No significant changeAnalgesic activity of glycine-substituted Semax analog
    Study

    ratn: not reported in source

    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    while the peptide with glycine instead of the methionine had no effect on pain sensitivity.
    2 context sentences
    Summary · context
    The peptides were administered intraperitoneally at doses of 0.015, 0.05 and 0.5 mg/kg.
    Summary · context
    Rat pain sensitivity was assessed using the paw-withdrawal test.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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