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Study · Animal study (in vivo) · rat · 2006

2 results

Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptor subunit and PSD-95 gene transcript levels.

Le Grevès M, Zhou Q, Berg M, Le Grevès P, Fhölenhag K, Meyerson B, Nyberg F

Experimental brain research22 Apr 2006Cited by 70 (Europe PMC)

PMID16633806 (opens in a new tab)DOI10.1007/s00221-006-0438-2 (opens in a new tab)PepBankPUB-16633806
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, rhGH improved spatial memory performance versus untreated controls on the second and third trial days.

    In plain wordsIn rats without a pituitary gland, rhGH improved spatial memory compared with untreated controls on the second and third trial days.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSpatial memory on second and third trial days
    Study

    ratn: not reported in source

    Male hypophysectomized rats
    Comparator
    Untreated control animals
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The rhGH-treated group performed significantly better in the spatial memory task than the control animals on the second and third trial days.
    2 context sentences
    Summary · context
    This study was designed to examine the beneficial effects of recombinant human GH (rhGH) on cognitive function in male rats with multiple hormone deficiencies resulting from hypophysectomy (Hx).
    Summary · context
    The performance of an rhGH-treated group and an untreated control group was appraised in the Morris water maze (MWM).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, further training eliminated the spatial performance difference between rhGH-treated and untreated groups.

    In plain wordsIn rats without a pituitary gland, further training removed the spatial performance difference between rhGH and untreated groups.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeSpatial memory after further training
    Study

    ratn: not reported in source

    Male hypophysectomized rats
    Comparator
    Untreated control animals
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further training eliminated this difference between the groups.
    3 context sentences
    Summary · context
    The rhGH-treated group performed significantly better in the spatial memory task than the control animals on the second and third trial days.
    Summary · context
    This study was designed to examine the beneficial effects of recombinant human GH (rhGH) on cognitive function in male rats with multiple hormone deficiencies resulting from hypophysectomy (Hx).
    Summary · context
    The performance of an rhGH-treated group and an untreated control group was appraised in the Morris water maze (MWM).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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