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Study · Measured the body's own peptide · 2006

2 results

The short chain sugar acid, 2-buten-4-olide, activates oxytocin-secreting neurons but not arginine vasopressin-secreting neurons in the hypothalamus of rats.

Kawasaki M, Yamaga C, Onaka T, Saito J, Mera T, Hashimoto H, Fujihara H, Okimoto N, Ohnishi H, Nakamura T, Ueta Y

Brain research17 Apr 2006Cited by 5 (Europe PMC)

PMID16616049 (opens in a new tab)DOI10.1016/j.brainres.2006.02.099 (opens in a new tab)PepBankPUB-16616049
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, intraperitoneal 2-buten-4-olide significantly increased plasma oxytocin levels 15-60 min after administration.

    In plain wordsIn rats, a sugar acid raised the body's own oxytocin levels in blood within 15 to 60 minutes.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin level after 2-buten-4-olide
    Study

    ratn: not reported in source

    in vivo, hypothalamo-neurohypophyseal system
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    Plasma oxytocin (OXT) levels were significantly increased 15-60 min after i.p. administration of 2-B4O (100 mg/kg)
    1 context sentence
    Summary · context
    The effects of intraperitoneal (i.p.) administration of 2-buten-4-olide (2-B4O), an endogenous sugar acid, on the hypothalamo-neurohypophyseal system were examined in rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, 2-buten-4-olide induced Fos-like immunoreactivity predominantly in oxytocin-secreting neurons of the paraventricular and supraoptic nuclei.

    In plain wordsIn rats, a sugar acid switched on the brain cells that make the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseFos-like immunoreactivity in oxytocin neurons after 2-buten-4-olide
    Study

    ratn: not reported in source

    in vivo, hypothalamo-neurohypophyseal system
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    Dual immunostaining revealed that Fos-like immunoreactivity (LI) was predominantly observed in OXT-secreting neurons in the paraventricular (PVN) and the supraoptic nuclei (SON) 120 min after i.p. administration of 2-B4O.
    1 context sentence
    Summary · context
    The effects of intraperitoneal (i.p.) administration of 2-buten-4-olide (2-B4O), an endogenous sugar acid, on the hypothalamo-neurohypophyseal system were examined in rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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