Skip to content

Study · Animal study (in vivo) · mouse · 2005

5 results

Effects of combined long-term treatment with a growth hormone-releasing hormone analogue and a growth hormone secretagogue in the growth hormone-releasing hormone knock out mouse.

Fintini D, Alba M, Schally AV, Bowers CY, Parlow AF, Salvatori R

Neuroendocrinology1 Jan 2005Cited by 12 (Europe PMC)

PMID16601359 (opens in a new tab)DOI10.1159/000092520 (opens in a new tab)PepBankPUB-16601359
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In GHRHKO mice, adding GHRP‑2 to JI-38 gave higher body length than JI-38 alone.

    In plain wordsIn mice lacking GHRH, adding GHRP‑2 to JI-38 made them longer than JI-38 alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseBody length, JI-38 plus GHRP-2 versus JI-38 alone
    Study

    mousen: not reported in source

    GHRH knockout (GHRHKO) mice
    Comparator
    JI-38 alone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Animals treated with JI-38+GHRP-2 reached higher body length and weight than animals treated with JI-38 alone.
    2 context sentences
    Summary · context
    We treated GHRHKO mice for 5 weeks (from week 1 to week 6 of age) with the GHRH analogue JI-38 alone, or in combination with a GHS (GHRP-2), and at the end of the treatment we examined their response to an acute stimulus with GHRP-2 or GHRP-2 plus JI-38.
    Summary · context
    We used placebo-treated GHRHKO mice and animals heterozygous for the GHRHKO allele as controls.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In GHRHKO mice, adding GHRP‑2 to JI-38 gave higher body weight than JI-38 alone.

    In plain wordsIn mice lacking GHRH, adding GHRP‑2 to JI-38 gave higher body weight than JI-38 alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseBody weight, JI-38 plus GHRP-2 versus JI-38 alone
    Study

    mousen: not reported in source

    GHRH knockout (GHRHKO) mice
    Comparator
    JI-38 alone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Animals treated with JI-38+GHRP-2 reached higher body length and weight than animals treated with JI-38 alone.
    2 context sentences
    Summary · context
    We treated GHRHKO mice for 5 weeks (from week 1 to week 6 of age) with the GHRH analogue JI-38 alone, or in combination with a GHS (GHRP-2), and at the end of the treatment we examined their response to an acute stimulus with GHRP-2 or GHRP-2 plus JI-38.
    Summary · context
    We used placebo-treated GHRHKO mice and animals heterozygous for the GHRHKO allele as controls.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In GHRHKO mice, correction of somatotrope cell hypoplasia was similar with JI-38 alone and with JI-38 plus GHRP‑2.

    In plain wordsIn mice lacking GHRH, adding GHRP‑2 to JI-38 did not change how well pituitary growth hormone cells recovered.

    Peptide
    GHRP-2
    Outcome
    No significant changeCorrection of somatotrope hypoplasia, with or without GHRP-2
    Study

    mousen: not reported in source

    GHRH knockout (GHRHKO) mice
    Comparator
    JI-38 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    All the animals receiving JI-38 (with or without GHRP-2) showed similar correction of somatotrope cell hypoplasia.
    2 context sentences
    Summary · context
    We treated GHRHKO mice for 5 weeks (from week 1 to week 6 of age) with the GHRH analogue JI-38 alone, or in combination with a GHS (GHRP-2), and at the end of the treatment we examined their response to an acute stimulus with GHRP-2 or GHRP-2 plus JI-38.
    Summary · context
    We used placebo-treated GHRHKO mice and animals heterozygous for the GHRHKO allele as controls.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In GHRHKO mice, no animal showed a serum GH response to acute stimulation with GHRP‑2 alone.

    In plain wordsIn mice lacking GHRH, GHRP‑2 alone did not trigger a growth hormone rise in the blood.

    Peptide
    GHRP-2
    Outcome
    No significant changeSerum GH response to acute GHRP-2 alone
    Study

    mousen: not reported in source

    GHRH knockout (GHRHKO) mice
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    None of the GHRHKO animals showed a serum GH response to the acute stimulation with GHRP-2 alone
    2 context sentences
    Summary · context
    We treated GHRHKO mice for 5 weeks (from week 1 to week 6 of age) with the GHRH analogue JI-38 alone, or in combination with a GHS (GHRP-2), and at the end of the treatment we examined their response to an acute stimulus with GHRP-2 or GHRP-2 plus JI-38.
    Summary · context
    We used placebo-treated GHRHKO mice and animals heterozygous for the GHRHKO allele as controls.

Studies that did not test the peptide alone1

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In GHRHKO mice, both JI-38-treated groups responded with a serum GH rise to the combined JI-38 plus GHRP‑2 acute test.

    In plain wordsIn mice lacking GHRH, the treated groups raised blood growth hormone when given JI-38 and GHRP‑2 together.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum GH response to acute JI-38 plus GHRP-2
    Study

    mousen: not reported in source

    GHRH knockout (GHRHKO) mice
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    while both treated groups responded to the combined test with JI-38 + GHRP-2.
    2 context sentences
    Summary · context
    We treated GHRHKO mice for 5 weeks (from week 1 to week 6 of age) with the GHRH analogue JI-38 alone, or in combination with a GHS (GHRP-2), and at the end of the treatment we examined their response to an acute stimulus with GHRP-2 or GHRP-2 plus JI-38.
    Summary · context
    We used placebo-treated GHRHKO mice and animals heterozygous for the GHRHKO allele as controls.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.