In three patients of the original Kostmann family with severe congenital neutropenia, periodontal disease occurred despite normal neutrophil counts, and their neutrophils were deficient in antibacterial peptides; the authors attribute this to a deficiency of the body's own LL‑37.
In plain wordsThree patients with a rare neutrophil disorder had gum disease and neutrophils low in antibacterial peptides; authors link this to the body's own LL‑37.
- Peptide
- LL-37
- Outcome
- DecreaseAntibacterial peptide content of neutrophils
- Study
n = 3
- Outcome group
- Infection and antimicrobial activity · Immune and inflammation
Source sentences
Three patients had periodontal disease, despite normal ANC and professional dental care, and had neutrophils deficient in antibacterial peptides.
2 context sentences(design, population, supporting numbers)
the deficiency of the antibacterial peptide LL-37 probably explains their chronic periodontal disease.
We studied the periodontal disease in the four surviving patients belonging to the family originally described by Kostmann.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.