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Study · Randomized controlled trial · n = 56 · 2007

3 results

The effect of calcitonin on beta-endorphin levels in postmenopausal osteoporotic patients with back pain.

Ofluoglu D, Akyuz G, Unay O, Kayhan O

Clinical rheumatology31 Mar 2006Cited by 27 (Europe PMC)

PMID16575494 (opens in a new tab)DOI10.1007/s10067-006-0228-z (opens in a new tab)PepBankPUB-16575494
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis and back pain, salmon calcitonin improved pain scores more than placebo after 2 weeks (p<0.05).

    In plain wordsIn women with osteoporosis and back pain, salmon calcitonin improved pain more than placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    Direction not reportedPain scores
    Study

    n = 56

    Comparator
    Placebo with shared calcium
    Analysis
    Secondary
    Outcome group
    Pain · Musculoskeletal
    Studied dose
    100 IU · subcutaneous · 2 weeksAs given in this study (human).

    Source sentences

    Summary
    Although pain and QOL scores were improved at the end of the second week in both groups (p<0.05), the improvement in the treatment group was more significant when compared with the placebo group (p<0.05).
    2 context sentences
    Summary · context
    There were 30 patients with a mean age of 58.2+/-5.4 years in the treatment group and 26 patients with a mean age of 58.8+/-5.2 years in the placebo group in this randomized, placebo-controlled study.
    Summary · context
    The patients subcutaneously received 100 IU salmon calcitonin or placebo injections and 1,000 mg elementary calcium for 2 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis and back pain, salmon calcitonin improved quality of life more than placebo after 2 weeks (p<0.05).

    In plain wordsIn women with osteoporosis and back pain, salmon calcitonin improved quality of life more than placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    Direction not reportedQuality of life
    Study

    n = 56

    Comparator
    Placebo with shared calcium
    Analysis
    Secondary
    Outcome group
    Quality of life · Whole body
    Studied dose
    100 IU · subcutaneous · 2 weeksAs given in this study (human).

    Source sentences

    Summary
    Although pain and QOL scores were improved at the end of the second week in both groups (p<0.05), the improvement in the treatment group was more significant when compared with the placebo group (p<0.05).
    2 context sentences
    Summary · context
    There were 30 patients with a mean age of 58.2+/-5.4 years in the treatment group and 26 patients with a mean age of 58.8+/-5.2 years in the placebo group in this randomized, placebo-controlled study.
    Summary · context
    The patients subcutaneously received 100 IU salmon calcitonin or placebo injections and 1,000 mg elementary calcium for 2 weeks.
  3. 03HumanRandomized controlled trialMechanism

    In women with postmenopausal osteoporosis and back pain, salmon calcitonin increased plasma beta-endorphin versus placebo at the second week (p<0.001).

    In plain wordsIn women with osteoporosis and back pain, salmon calcitonin increased a natural pain-related peptide compared with placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasePlasma beta-endorphin
    Study

    n = 56

    Comparator
    Placebo with shared calcium
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    100 IU · subcutaneous · 2 weeksAs given in this study (human).

    Measurements

    P value
    < 0.001
    versus placebo

    Source sentences

    Summary
    We found that plasma beta-endorphin levels in the treatment group were significantly higher than the placebo group at the end of the second week (p<0.001).
    2 context sentences
    Summary · context
    There were 30 patients with a mean age of 58.2+/-5.4 years in the treatment group and 26 patients with a mean age of 58.8+/-5.2 years in the placebo group in this randomized, placebo-controlled study.
    Summary · context
    The patients subcutaneously received 100 IU salmon calcitonin or placebo injections and 1,000 mg elementary calcium for 2 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase 4NCT00754884

Calcitonin in the Treatment of Fibromyalgia

Unidad de Investigacion en Enfermedades Cronico-Degenerativasn = 0Oct 2008 to Feb 2009

Fibromyalgia

Trial pageClinicalTrials.govUpdated 4 Dec 2015

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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