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Study · Not a test of the peptide alone · 2006

14 results

[An effect of long-term cerebrolysin therapy in combination with neuroleptics on behavioral and cognitive disturbances in endogenous childhood autism].

Radzivil MG, Bashina VM

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2006Cited by 1 (Europe PMC)

PMID16548370 (opens in a new tab)PepBankPUB-16548370
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone14

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 01HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics produced significant or very significant improvement after the first course in 38% of patients.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics produced marked improvement after the first course in 38% of patients.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseImprovement after first course
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Patients with significant or very significant improvement
    38%
    after the 1st Cerebrolysin course

    Source sentences

    Summary
    Significant or very significant improvement was achieved after the 1st Cerebrolysin course in 38% patients, after the 2nd course in more than 50% and to the end of the follow-up (180th day) in 71% of patients.
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 02HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics produced significant or very significant improvement after the second course in more than 50% of patients.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics produced marked improvement after the second course in more than 50% of patients.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseImprovement after second course
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Patients with significant or very significant improvement
    > 50%
    after the 2nd Cerebrolysin course

    Source sentences

    Summary
    Significant or very significant improvement was achieved after the 1st Cerebrolysin course in 38% patients, after the 2nd course in more than 50% and to the end of the follow-up (180th day) in 71% of patients.
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  3. 03HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics produced significant or very significant improvement by day 180 in 71% of patients.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics produced marked improvement by day 180 in 71% of patients.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseImprovement at follow-up end
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Patients with significant or very significant improvement
    71%
    end of follow-up (180th day)

    Source sentences

    Summary
    Significant or very significant improvement was achieved after the 1st Cerebrolysin course in 38% patients, after the 2nd course in more than 50% and to the end of the follow-up (180th day) in 71% of patients.
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  4. 04HumanNot a test of Cerebrolysin aloneNon-randomized trialSafety outcome

    In children with autism, no deterioration occurred during Cerebrolysin plus neuroleptic treatment.

    In plain wordsIn children with autism, no deterioration occurred during Cerebrolysin plus neuroleptic treatment.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableDeterioration
    Study

    n = 25

    Outcome group
    Adverse events · Nervous system and cognition

    Source sentences

    Summary
    There were no cases of deterioration during the trial.
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  5. 05HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics reduced CARS scores from 37.7 to 32.6 by day 180 versus baseline (p < 0.001).

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics reduced autism severity compared with baseline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCARS autism severity
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    CARS score
    37.7 scores
    day 0 (baseline)
    CARS score
    32.6 scores
    day 180
    P value for CARS autism severity
    < 0.001 p value
    Cerebrolysin plus neuroleptics, all assessments compared with baseline through day 180

    Source sentences

    Summary
    The autism severity as measured by the CARS scale consistently decreased from the day 0 to the day 180--from 37.7 to 32.6 scores, respectively (p < 0.001) in all assessments as compared with the baseline.
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  6. 06HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly decreased mental retardation by 0.2 years by study end.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics reduced the reported measure of mental retardation by study end.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMental retardation
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Decrease in mental retardation
    0.2 years
    by study end

    Source sentences

    Summary
    To the end of the study, the patients demonstrated a significant decrease in mental retardation by 0.2 years.
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  7. 07HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved cognitive activity.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved cognitive activity.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCognitive activity
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  8. 08HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved attention during tasks.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved attention during tasks.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAttention during tasks
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  9. 09HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved self-service by 0.3 years.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved self-care.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSelf-service
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Improvement in self-service
    0.3 years
    by study end

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  10. 10HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved receptive speech.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved speech understanding.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseReceptive speech
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  11. 11HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved expressive speech.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved expressive speech.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseExpressive speech
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  12. 12HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved cognitive performance.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved cognitive performance.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCognitive performance
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Improvement in cognitive performance and perception (reported together)
    0.2 years
    Cerebrolysin plus neuroleptics, cognitive performance and perception reported together

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  13. 13HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved perception, with a reported 0.2-year gain for cognitive performance and perception.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved perception.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePerception
    Study

    n = 25

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Improvement in cognitive performance and perception (reported together)
    0.2 years
    by study end

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  14. 14HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In children with autism, Cerebrolysin plus neuroleptics significantly improved fine motor function by 0.1 years.

    In plain wordsIn children with autism, Cerebrolysin plus neuroleptics improved fine motor function.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseFine motor function
    Study

    n = 25

    Outcome group
    Exercise and physical function · Nervous system and cognition

    Measurements

    Improvement in fine motor function
    0.1 years
    by study end

    Source sentences

    Summary
    A statistically significant improvement was achieved in cognitive activity, attention during task performing as well as in self-service (by 0.3 years), receptive and expressive speech, cognitive performance and perception (by 0.2 years), fine motor function (by 0.1 years).
    3 context sentences
    Summary · context
    An open prospective clinical study included 25 patients with childhood autism aged from 3 to 8 years (mean age 5 years 11 months).
    Summary · context
    Patients received 2 therapeutic courses (15 intramuscular Cerebrolysin injections of 1.0 ml every other day per course) with 2 months interval and basic antipsychotic therapy using typical neuroleptics in age-adjusted dosages.
    Summary · context
    The duration of the study was 180 days.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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