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Study · Animal study (in vivo) · mouse · 2005

4 results

Construction and application of a yeast expression system for thymosin alpha1.

Chen F, Chen XM, Chen Z, Jiang HL, Pan XP, Hu ZR, Liu RH, Chen XM

Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al1 Dec 2005Cited by 2 (Europe PMC)

PMID16524246 (opens in a new tab)DOI10.32604/biocell.2005.29.253 (opens in a new tab)PepBankPUB-16524246
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immunosuppressed mice, dried yeast containing Talpha1 increased CD8+ levels significantly versus empty yeast.

    In plain wordsIn mice with a weakened immune system, yeast making thymosin alpha‑1 raised CD8+ immune cells more than empty yeast.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD8+ level, yeast-expressed Talpha1
    Study

    mousen: not reported in source

    Balb/c mice immunosuppressed with cyclophosphamide
    Comparator
    Empty yeast (negative control)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral (dried yeast)As given in this study (mouse).

    Source sentences

    Summary
    Compared with the negative control group, both dried yeast containing pYEST2-Talpha1 and synthesized Talpha1 peptide can significantly increase the CD8+ level (22.74 +/- 1.09 and 18.77 +/- 4.72 vs 7.49 +/- 2.14, p < 0.01), while both of them had little effect on the CD4+ lymphocytes (61.86 +/- 6.94…
    1 context sentence
    Summary · context
    Dried yeast containing pYEST2-Talpha1 was fed to Balb/c mice whose immunities were inhibited by cyclophosphamide in advance.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In immunosuppressed mice, synthesized Talpha1 peptide increased CD8+ levels significantly versus empty yeast.

    In plain wordsIn mice with a weakened immune system, synthetic thymosin alpha‑1 raised CD8+ immune cells more than empty yeast.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD8+ level, synthesized Talpha1
    Study

    mousen: not reported in source

    Balb/c mice immunosuppressed with cyclophosphamide
    Comparator
    Empty yeast (negative control)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with the negative control group, both dried yeast containing pYEST2-Talpha1 and synthesized Talpha1 peptide can significantly increase the CD8+ level (22.74 +/- 1.09 and 18.77 +/- 4.72 vs 7.49 +/- 2.14, p < 0.01), while both of them had little effect on the CD4+ lymphocytes (61.86 +/- 6.94…
    1 context sentence
    Summary · context
    Dried yeast containing pYEST2-Talpha1 was fed to Balb/c mice whose immunities were inhibited by cyclophosphamide in advance.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In immunosuppressed mice, dried yeast containing Talpha1 had little effect on CD4+ lymphocytes versus empty yeast.

    In plain wordsIn mice with a weakened immune system, yeast making thymosin alpha‑1 did not clearly change CD4+ cells, compared with empty yeast.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeCD4+ level, yeast-expressed Talpha1
    Study

    mousen: not reported in source

    Balb/c mice immunosuppressed with cyclophosphamide
    Comparator
    Empty yeast (negative control)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · oral (dried yeast)As given in this study (mouse).

    Source sentences

    Summary
    Compared with the negative control group, both dried yeast containing pYEST2-Talpha1 and synthesized Talpha1 peptide can significantly increase the CD8+ level (22.74 +/- 1.09 and 18.77 +/- 4.72 vs 7.49 +/- 2.14, p < 0.01), while both of them had little effect on the CD4+ lymphocytes (61.86 +/- 6.94…
    1 context sentence
    Summary · context
    Dried yeast containing pYEST2-Talpha1 was fed to Balb/c mice whose immunities were inhibited by cyclophosphamide in advance.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In immunosuppressed mice, synthesized Talpha1 peptide had little effect on CD4+ lymphocytes versus empty yeast.

    In plain wordsIn mice with a weakened immune system, synthetic thymosin alpha‑1 did not clearly change CD4+ cells, compared with empty yeast.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeCD4+ level, synthesized Talpha1
    Study

    mousen: not reported in source

    Balb/c mice immunosuppressed with cyclophosphamide
    Comparator
    Empty yeast (negative control)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with the negative control group, both dried yeast containing pYEST2-Talpha1 and synthesized Talpha1 peptide can significantly increase the CD8+ level (22.74 +/- 1.09 and 18.77 +/- 4.72 vs 7.49 +/- 2.14, p < 0.01), while both of them had little effect on the CD4+ lymphocytes (61.86 +/- 6.94…
    1 context sentence
    Summary · context
    Dried yeast containing pYEST2-Talpha1 was fed to Balb/c mice whose immunities were inhibited by cyclophosphamide in advance.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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