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Study · Animal study (in vivo) · rat · 2006

3 results

[Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration].

Shevchenko KV, Nagaev IIu, Alfeeva LIu, Andreeva LA, Kamenskiĭ AA, Levitskaia NG, Shevchenko VP, Grivennikov IA, Miasoedov NF

Bioorganicheskaia khimiia1 Jan 2006Cited by 15 (Europe PMC)

PMID16523722 (opens in a new tab)DOI10.1134/s1068162006010055 (opens in a new tab)PepBankPUB-16523722
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, 0.093% of the total administered radioactivity per gram was found in the brain 2 minutes after intranasal labeled Semax.

    In plain wordsIn rats, a small share of nasal Semax reached the brain within 2 minutes.

    Peptide
    Semax
    Outcome
    Not applicableBrain radioactivity 2 minutes after intranasal dose
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    50 microg/kg · intranasalAs given in this study (rat).

    Measurements

    Brain radioactivity
    0.093 % of dose per gram
    2 min after administration

    Source sentences

    Summary
    It was demonstrated that 0.093% of the total introduced radioactivity per gram can be found in the rat brain 2 min after the administration, 80% of this radioactivity belonged to Semax, and the rest, to its metabolites.
    1 context sentence
    Summary · context
    The labeled peptide was used for studying the kinetics of Semax penetration into rat brain and blood after its intranasal administration (50 microg/kg, 20 microl of solution) to nonbred white rats of body mass 200-250 g.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, 80% of the radioactivity found in the brain at 2 minutes belonged to Semax and the rest to its metabolites.

    In plain wordsIn rats, most of the label found in the brain at 2 minutes was still intact Semax.

    Peptide
    Semax
    Outcome
    Not applicableShare of brain radioactivity that was intact Semax
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    50 microg/kg · intranasalAs given in this study (rat).

    Measurements

    Intact Semax share of brain radioactivity
    80%
    2 min after administration

    Source sentences

    Summary
    It was demonstrated that 0.093% of the total introduced radioactivity per gram can be found in the rat brain 2 min after the administration, 80% of this radioactivity belonged to Semax, and the rest, to its metabolites.
    1 context sentence
    Summary · context
    The labeled peptide was used for studying the kinetics of Semax penetration into rat brain and blood after its intranasal administration (50 microg/kg, 20 microl of solution) to nonbred white rats of body mass 200-250 g.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, Semax underwent rapid enzymatic degradation, with Pro-Gly-Pro prevailing in biological samples.

    In plain wordsIn rats, Semax broke down fast, and the small peptide Pro-Gly-Pro was the main fragment found.

    Peptide
    Semax
    Outcome
    Not applicableEnzymatic degradation of Semax
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    50 microg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The peptide undergoes rapid enzymatic degradation, with the tripeptide Pro-Gly-Pro prevailing in biological samples relative to the total content of Semax and its metabolites.
    1 context sentence
    Summary · context
    The labeled peptide was used for studying the kinetics of Semax penetration into rat brain and blood after its intranasal administration (50 microg/kg, 20 microl of solution) to nonbred white rats of body mass 200-250 g.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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