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Study · Animal study (in vivo) · rat · 2006

5 results

Paraventricular hypothalamic influences on spinal nociceptive processing.

Condés-Lara M, Rojas-Piloni G, Martínez-Lorenzana G, Rodríguez-Jiménez J, López Hidalgo M, Freund-Mercier MJ

Brain research23 Feb 2006Cited by 69 (Europe PMC)

PMID16497280 (opens in a new tab)DOI10.1016/j.brainres.2006.01.050 (opens in a new tab)PepBankPUB-16497280
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In anesthetized rats, oxytocin applied directly on the spinal cord selectively blocked A-delta and C fibre responses, like paraventricular nucleus stimulation.

    In plain wordsIn anesthetized rats, oxytocin put on the spinal cord blocked pain-fibre signals, like stimulation of a brain area did.

    Peptide
    Oxytocin
    Outcome
    DecreaseSpinal A-delta and C fibre evoked responses after oxytocin
    Study

    ratn: not reported in source

    anesthetized rat, spinal dorsal horn recording
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · applied directly on the spinal cordAs given in this study (rat).

    Source sentences

    Summary
    Similar effects were observed when oxytocin (OT) was applied directly on the spinal cord.
    2 context sentences
    Summary · context
    We observed a selective blockage of A-delta and C fibers related to the duration of the train stimulus duration.
    Summary · context
    In anesthetized rats, we recorded single units at the L4-L5 spinal dorsal horn level and stimulated the peripheral receptive field.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, a specific oxytocin antagonist reversed the effects of oxytocin on spinal responses in a dose-dependent manner.

    In plain wordsIn anesthetized rats, a drug that blocks the oxytocin receptor reversed the effects of oxytocin on spinal nerve signals.

    Peptide
    Oxytocin
    Outcome
    Not applicableReversal of oxytocin effect by oxytocin antagonist
    Study

    ratn: not reported in source

    anesthetized rat, spinal dorsal horn recording
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · applied directly on the spinal cordAs given in this study (rat).

    Source sentences

    Summary
    The effects of OT and of PV electrical stimulation were reversed in a dose-dependent manner by application of the specific OT antagonist (OTA).
    1 context sentence
    Summary · context
    In anesthetized rats, we recorded single units at the L4-L5 spinal dorsal horn level and stimulated the peripheral receptive field.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In anesthetized rats, the blocking effects of spinal oxytocin and paraventricular stimulation on dorsal horn responses were seen in cells with reduced wind-up and in cells with a clear wind-up response.

    In plain wordsIn anesthetized rats, the signal-blocking effects of oxytocin were seen in both types of spinal nerve cells that were tested.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin effect in cells with and without wind-up
    Study

    ratn: not reported in source

    anesthetized rat, spinal dorsal horn recording
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · applied directly on the spinal cordAs given in this study (rat).

    Source sentences

    Summary
    These effects were observed in cells with reduced wind-up and cells displaying a clear wind-up response to peripheral stimulation.
    1 context sentence
    Summary · context
    In anesthetized rats, we recorded single units at the L4-L5 spinal dorsal horn level and stimulated the peripheral receptive field.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a loose sciatic nerve ligature, intrathecal oxytocin significantly reduced the response in the mechanical test.

    In plain wordsIn rats with a nerve injury, oxytocin given into the spinal canal reduced pain responses to touch.

    Peptide
    Oxytocin
    Outcome
    DecreaseMechanical hyperalgesia and allodynia after intrathecal oxytocin
    Study

    ratn: not reported in source

    rats with loose sciatic nerve ligature and chronic intrathecal catheter
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    15 microl of 10(-6) M · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Our results show a significant reduction in the mechanical and thermal test after the administration of 15 microl of 10(-6) M OT.
    1 context sentence
    Summary · context
    In order to obtain a behavioral correlation, we used rats with a loose ligature of the sciatic nerve and a chronic intrathecal catheter reaching the L4-L5 spinal cord level. We tested the hyperalgesia and allodynia of these animals using von Frey filaments and the application of acetone to the hind paws.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a loose sciatic nerve ligature, intrathecal oxytocin significantly reduced the response in the thermal test.

    In plain wordsIn rats with a nerve injury, oxytocin given into the spinal canal reduced pain responses in the thermal test.

    Peptide
    Oxytocin
    Outcome
    DecreaseThermal hyperalgesia and allodynia after intrathecal oxytocin
    Study

    ratn: not reported in source

    rats with loose sciatic nerve ligature and chronic intrathecal catheter
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    15 microl of 10(-6) M · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Our results show a significant reduction in the mechanical and thermal test after the administration of 15 microl of 10(-6) M OT.
    1 context sentence
    Summary · context
    In order to obtain a behavioral correlation, we used rats with a loose ligature of the sciatic nerve and a chronic intrathecal catheter reaching the L4-L5 spinal cord level. We tested the hyperalgesia and allodynia of these animals using von Frey filaments and the application of acetone to the hind paws.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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