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Study · Non-randomized trial · 2006

5 results

A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide.

Lindsay R, Cosman F, Zhou H, Bostrom MP, Shen VW, Cruz JD, Nieves JW, Dempster DW

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research21 Nov 2005Cited by 199 (Europe PMC)

PMID16491283 (opens in a new tab)DOI10.1359/jbmr.051109 (opens in a new tab)PepBankPUB-16491283
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In human bone biopsies, teriparatide stimulated cancellous bone formation compared with untreated controls.

    In plain wordsIn people, teriparatide increased cancellous bone formation compared with untreated controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCancellous bone formation
    Study

    n: not reported in source

    Comparator
    Control subjects without hPTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 monthAs given in this study (human).

    Source sentences

    Summary
    Treatment with hPTH(1-34) dramatically stimulated bone formation on cancellous and endocortical surfaces.
    2 context sentences
    Summary · context
    We used this method to investigate the early effects of teriparatide [hPTH(1-34)] treatment on bone formation.
    Summary · context
    The results were compared with those from a group of control subjects who were quadruple-labeled, but did not receive hPTH(1-34).
  2. 02HumanNon-randomized trialEfficacy outcome

    In human bone biopsies, teriparatide stimulated endocortical bone formation compared with untreated controls.

    In plain wordsIn people, teriparatide increased endocortical bone formation compared with untreated controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEndocortical bone formation
    Study

    n: not reported in source

    Comparator
    Control subjects without hPTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 monthAs given in this study (human).

    Source sentences

    Summary
    Treatment with hPTH(1-34) dramatically stimulated bone formation on cancellous and endocortical surfaces.
    2 context sentences
    Summary · context
    We used this method to investigate the early effects of teriparatide [hPTH(1-34)] treatment on bone formation.
    Summary · context
    The results were compared with those from a group of control subjects who were quadruple-labeled, but did not receive hPTH(1-34).
  3. 03HumanNon-randomized trialEfficacy outcome

    In human bone biopsies, teriparatide increased the linear rate of matrix apposition.

    In plain wordsIn people, teriparatide increased the rate of bone matrix deposition.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseLinear matrix apposition rate
    Study

    n: not reported in source

    Comparator
    Control subjects without hPTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 monthAs given in this study (human).

    Source sentences

    Summary
    This was achieved by both an increase in the linear rate of matrix apposition and extension of the bone-forming surface.
    3 context sentences
    Summary · context
    Treatment with hPTH(1-34) dramatically stimulated bone formation on cancellous and endocortical surfaces.
    Summary · context
    We used this method to investigate the early effects of teriparatide [hPTH(1-34)] treatment on bone formation.
    Summary · context
    The results were compared with those from a group of control subjects who were quadruple-labeled, but did not receive hPTH(1-34).
  4. 04HumanNon-randomized trialEfficacy outcome

    In human bone biopsies, teriparatide extended the bone-forming surface.

    In plain wordsIn people, teriparatide increased the surface where bone formed.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone-forming surface
    Study

    n: not reported in source

    Comparator
    Control subjects without hPTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 monthAs given in this study (human).

    Source sentences

    Summary
    This was achieved by both an increase in the linear rate of matrix apposition and extension of the bone-forming surface.
    3 context sentences
    Summary · context
    Treatment with hPTH(1-34) dramatically stimulated bone formation on cancellous and endocortical surfaces.
    Summary · context
    We used this method to investigate the early effects of teriparatide [hPTH(1-34)] treatment on bone formation.
    Summary · context
    The results were compared with those from a group of control subjects who were quadruple-labeled, but did not receive hPTH(1-34).
  5. 05HumanNon-randomized trialEfficacy outcome

    In human bone biopsies after teriparatide, new bone appeared on quiescent surfaces, with possible encroachment from adjacent resorption cavities.

    In plain wordsIn people given teriparatide, bone formed on inactive surfaces, possibly partly through extension from nearby resorption cavities.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseModeling-based bone formation
    Study

    n: not reported in source

    Comparator
    Control subjects without hPTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 monthAs given in this study (human).

    Source sentences

    Summary
    New bone was deposited on previously quiescent surfaces (i.e., modeling-based formation), but a proportion of this could occur by encroachment from adjacent resorption cavities.
    2 context sentences
    Summary · context
    We used this method to investigate the early effects of teriparatide [hPTH(1-34)] treatment on bone formation.
    Summary · context
    The results were compared with those from a group of control subjects who were quadruple-labeled, but did not receive hPTH(1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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